中西医结合治疗再生障碍性贫血20例

Integrated Traditional Chinese and Western Medicine in Treating 20 Cases of Aplastic Anemia

目的研究化血汤治疗慢性再生障碍性贫血的疗效及机制。方法将36例再障患者分为化血汤配合西药治疗组(治疗组,20例)和单纯西药治疗组(对照组,16例),分别观察其临床疗效及治疗前后患者外周血清造血抑制活性和诱导细胞凋亡活性的变化情况。结果治疗组总有效率85.0%,明显高于对照组56.3%(P<0.05)。再障患者经有效治疗后其外周血清的造血抑制活性和凋亡诱导活性明显降低,加服化血汤可增强此种作用。结论化血汤配合西药治疗慢性再障效果明显优于单纯西药治疗组。通过降低再障患者血清造血抑制活性从而改善骨髓造血功能可能是化血汤治疗再障的药理机制之一。

Objective： To study the efficacy and mechanism of Hua Xue decoction in treating chronic aplastic anemia. Methods： 36 cases of patients with aplastic anemia were divided into Hua Xue decoction with western medicine group （ therapeutic group, 20 cases） and western medicine group （ control group, 16 cases）. We observed the clinical effects of each group, as well as the changes of hematopoietc inhibition activity and the induced cell apoptosis activity of the patients＇serum. Results ： The total effective rate of the therapeutic group was 85.0 %, obviously higher than 56.3 % of the control group （ P 〈 0.05 ）. After the treatment, the hematopoietic inhibition activity and the induced apoptosis activity of the patients＇serum decreased obviously. And taking Hua Xue decoction could reinforce this effect. Conclusion： Hua Xue decoction with western medicine has an significantly better effect than simple western medicine in treaiting aplastic anemia. By decreasing the patients＇serum hematopoietic inhibition activity to improve the marrow＇s hematopoietic function may be one of the pharmacological mechanism of Hua Xue decoction for treating aplastic anemia.