摘要
转录因子Pap1是裂殖酵母(Schizosaccharomyces pombe)应答H2O2氧化胁迫反应中的关键调控因子.高浓度的H2O2激活蛋白激酶Sty1途径清除过量的H2O2,使H2O2降至较低浓度再活化Pap1;低浓度的则直接氧化活化Pap1,导致Pap1快速向细胞核内运输从而激活Pap1相关基因的表达.本文综述了裂殖酵母中转录因子Pap1在不同浓度H2O2胁迫下的激活途径,以及蛋白激酶Sty1对Pap1激活的重要作用.
The transcription factor Papl is a key regulator of H2O2-induced responses in Schizosaccharomyces pombe. High concentrations of H2O2 activate the protein kinase Styl, which decomposes the excess of H2O2 and leads to an appropriate concentration for the subsequent activation of Papl. Low doses of H2O2 directly activate Papl by oxidation and result in the accumulation of Papl in the nucleus to turn on the expression of the Papl-dependent genes. This review mainly focuses on the activation of Papl by sensing different concentrations of H2O2, and the role of Styl in the activation of Papl in Schizosaccharomyces pombe.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2008年第5期398-402,共5页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家重点基础研究发展规划(973计划
No.2006CB100104)~~
