ACE基因多态与有氧能力训练效果的相关性分析

Analysis on Correlation between ACE Gene Polymorphisms and Aerobic Training Effect

目的:探讨耐力训练对心肺功能的影响与ACE基因I/D(插入/缺失)多态性的关联性,为长跑运动员基因选材提供标准与实验方法。方法:测定102名北方汉族新兵,经18周的5 km跑耐力训练前后最大耗氧量(VO_2max)和通气无氧闲(VT),并应用PCR-AFLP方法检测其ACE基因I/D多态,观察两者之间是否存在关联。结果:ID型和Ⅱ型的VO_2max变化率(Δ%)显著高于DD型(P<0.05);ΔVT时VO_2的变化率(Δ%)在基因型的组间差异有显著性(P<0.05),并且Ⅱ型的变化显著高于DD型(P<0.05)。结论:ACE基因I/D多态与耐力训练对心肺功能的影响有一定关联。其中,Ⅰ等位基因在VO_2max和VT的训练敏感性方面具有较明显的遗传优势,而Ⅱ基因型携带者对VT的耐力训练可能更敏感。

The purpose of this study was to investigate the cardiorespiratory function and the correlation between angiotensin-converting enzyme gene I/D （insertion/deletion） polymorphism and the sensitivity to aerobic endurance training in order to provide a criterion and experiment method for gene selecting of long-distance athletes. Through using Polymerase Chain Reaction techniques, this paper determined the ACE genotypes （Ⅱ, ID, DD） of 102 male Chinese army recruits. Before and after 18 wk of 5-km running training, the changes of VO2max and VT are tested. The result shows that the △VO2 max of ID and Ⅱ type is obviously higher than that of DD type（P〈0.05）, there is obviously difference on △VT/VO2 in different ACE genotype（P〈0.05）, the △VT/VO2 of Ⅱ type is obviously higher than that of DD type（P〈0.05）. It concludes that Ⅰ allele has obviously hereditary advantage on the sensitivity of aerobic training in VO2 max and VT, and Ⅱ type has relation with sensitivity of aerobic training in VT.