髓系白血病细胞DNA非同源末端连接能力的检测
被引量：1
摘要
DNA双链断裂（double-strand break，DSB）是最致命的DNA损伤，在人类DSB最主要的修复方式是非同源末端连接（non-homologous end joining，NHEJ）。大部分DNA损伤都能修复，不能修复或不恰当的修复会造成基因变异、肿瘤发生和细胞死亡。对DNA修复机制的研究正日益受到重视，我们实验室建立了一个用于临床标本的DNA双链断裂修复能力的检测体系，并对白血病细胞和正常骨髓细胞进行了检测。
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2008年第5期339-340,共2页
Chinese Journal of Hematology
基金
国家自然科学基金（30200335,30500218）
2004年江苏省135工程重点学科开放课题（135xy0411）
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同被引文献10
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1傅琤琤,王之敏,岑建农,胡绍燕,何军,邱桥成,陈子兴.用于临床标本的无细胞非同源末端连接检测体系的建立[J].苏州大学学报（医学版）,2005,25(2):241-244. 被引量：1
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