期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Ad5F35-IκBα△N重组腺病毒在柔红霉素诱导HL-60细胞凋亡中的作用 被引量：1

原文传递
导出
摘要 柔红霉素（DNR）是治疗急性白血病的常用药物，可诱导白血病细胞凋亡。DNR也是多药耐药肿瘤细胞耐药谱中最具代表性的细胞毒药物，许多白血病细胞对DNR具有一定的耐药性，大大影响了白血病的治疗效果。NF-κB是细胞核内重要的转录因子，它的激活被认为是许多肿瘤细胞对化疗药物产生耐药性的关键因素。
作者 刘志军 王光平
机构地区 湖南师范大学医学院检验系
出处 《中华血液学杂志》 CAS CSCD 北大核心 2008年第5期344-345,共2页 Chinese Journal of Hematology
基金 国家自然科学基金（30270575）
关键词 HL-60细胞凋亡 柔红霉素 重组腺病毒 IΚBΑ 耐药肿瘤细胞 急性白血病 治疗效果 细胞毒药物
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献9

二级参考文献120

  • 1Flens MJ,Zaman GJ, Van der valk P, et al. Tissue distribution of the multidrug resistance protein. Am J Pathol,1996,148 : 1 237.
  • 2Sukhai M, Piquette-Millerm M. Regulation of muhidrng resistance gene by stress signals. J Pharm Pharmaceut,2000,3(2) :268.
  • 3Hu XF, Slater A, Kantharidis P, et al. Altered muhidrug resistance phenotype caused by anthracycline analogues and cytosine arabinoside in myeloid leukemia. Blood, 1999,93(12) :4 086.
  • 4Hu XF, Slater A, Wall DM, et al. Rapid up-regulation of mdrl expression by anthracyclines in a classical multidrug resistant cell line. Br J Cancer,1995,71 (5) :931.
  • 5Kuo MT, Liu Z, Wei Y, et al. Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effctors of the phosphoinositide 3-kinase pathway that activate NF-KB signaling. Oncogene.2002.21 ( 13 ) :1945.
  • 6Epsztejn S, Glickstein H, Picard V,et al. Herritin subunit overexpression in erythroid cells reduces the oxidative stress response and induces muhidrug resistance properties. Blood,1999,94(10) :3 593.
  • 7Ortega R, Moretto P, Fajac A, et al. Quantitative mapping of platinum and essential trace metal in cisplatin resistant and sensitive human ovarian adenocarcinoma cells. Cell Mol Biol, 1996,42 ( 1 ) : 77.
  • 8Boland MP, Foster SJ, O'Neill LAJ. Daunorubicin activates NFKB and induces KB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells. J Biol Chem,1997,272(20):12952.
  • 9Reuther JY, Reuther GW, Cortez D, et al. A requirement for NF-kB activation in Bcr-Abl-mediated transformation. Genes Dev,1998, 12:968 -981.
  • 10Hamdane M, David-Cordonnier MH, D Halluin JC. Activation of p65 NF-kB protein by p210BCR-ABL in a myeloid cell line (p210BCR-ABL activates p65 NF-kB). Oncogene, 1997, 15:2267 - 2275.

共引文献7

同被引文献14

  • 1Hardt M, Chantaravisoot N, Tamanoi F. Activating mutations of TOR (target of rapamyein) [J]. Genes ceils, 2011, 16 (2): 141- 151.
  • 2Na M, Fan X. Design of Ad5F35 veeturs for eoordinaled dual gene expression in candidate human hematopoietic stem cells [J]. Exp Hematol, 2010, 38 (6): 446-452.
  • 3Matsui H, Sakurai F, Katayama K, et td. Enhanced transduction efficieney of fiber-subsfituted adenovirus vectors by the incor- poration of RGD peptides in two distinct regions of the adennvirus serotype 35 fiber knob [J]. Virus Res, 2011, 155 ( 1 ): 48-54.
  • 4Pichiorri F, Trapasso F, Palumbo T, et td. Preclinieal assessment of FHIT gene replacement therapy in truman leukemia using a chimeric adenovirus, Ad5 / F35 [J ]. Clin Cancer Res, 2006, 12 (11 Pt 1): 3494-3501.
  • 5Sakurai F, Nakashima K, Yamaguchi T, et td. Adenovirus serotype 35 vector-induced innate immune responses in dendritic cells derived from wild-type and human CD46-transgenic mice: Comparison with a fiber-substituted Ad vector containing fiber proteins of Ad serotype 35[J]. J Control Release, 2010, 148 (2): 212-218.
  • 6Ganesh S, Gonzalez-Edick M, Gibbons D, et (d. Evaluation of biodistribution of a fiber-chimeric, conditionally replication- competent (oncoly|ic) adenovims in CD46 receptor transgenic mice EJ]. Hum Gene Ther, 2009, 20 ( 10): 1201-1213.
  • 7Bayle JH, Grimley JS, Stankunas K, et ol. Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity [J]. Chem Biol, 2006,13 ( 1 ): 99-107.
  • 8Luo J, Deng ZL, Luo X, et al. A protocol for rapid generation of recombinant adenoviruses using the AdEasy system [J]. Nat Protoc, 2007, 2 (5): 1236-1947.
  • 9He TC, Zhou S, Da Costa LT, et al. A simplified system for generating recombinant adenoviruses IJ ]. Proe Natl Aead S('i USA, 1998, 95 (5): 2509-2514.
  • 10Rebel VI, Hartnett S, Denham J, et cd. Maturation and lineage- specific: expression of the coxsackie and adenovirus receptor in hematopoietie cells [ J ]. Stem Cells, 2000, 18 ( 3 ) : 176-182.

引证文献1

二级引证文献3

中华血液学杂志
2008年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部