氯胺酮灌胃、滴鼻对动物的作用

The Effect of Intragastric or Intranasal Ketamine in Animals

观察用市售氯胺酮注射剂给动物灌胃、滴鼻的作用并与静注比较。测得氯胺酮灌胃引起翻正反射消失的ＥＤ５０和ＬＤ５０分别为５２．８ｍｇ／ｋｇ和５７３．２ｍｇ／ｋｇ，分别为静注的３．８和７．６倍。氯胺酮１７２、２４５和３５０ｍｇ／ｋｇ灌胃，小鼠平均睡眠时间分别为５９．１、１３０．７和２５４．５ｍｉｎ，呈明显剂量依赖关系，但３个剂量组入睡潜伏期相似。兔每侧鼻孔分别滴入０．１、０．２和０．３ｍｌ氯胺酮，均引起家兔翻正反射消失。本工作为临床应用氯胺酮口服、滴鼻的可行性提供了动物实验依据，可以考虑在临床试用，建议厂家生产氯胺酮的口服和滴鼻制剂。

The effect of intragastric or intranasal ketamine for premedication was studied in animals.The hypnotic ED 50 and LD 50 of ketamine administered intragastircally in mice were 52 8 and 573 2 mg/kg respectively,which were 3 7 and 7 6 times of that given iv.Ketamine 172,245 or 350 mg/kg intragastrically induced a dose dependent loss of righting reflex for 59 1,130 7 and 254 5 min respectively.Intranasal administration of ketamine 0 1,0 2 or 0 3 ml induced loss of righting reflex in all rabbits studied.