腹部手术时芬太尼对糖耐量试验中β-内啡肽的影响

Effects of Fentanyl on the Plasma β Endorphin in Intravenous Glucose Tolerance Test during Abdominal Sugery

观察了不同剂量芬太尼在腹部手术时对糖耐量试验中β－ＥＰ的影响。２４例择期手术病人随机分成芬太尼用量１０μｇ／ｋｇ和１５μｇ／ｋｇ二组，分别于麻醉前基础状态和手术切皮后６０ｍｉｎ进行静脉法葡萄糖耐量试验。结果表明，血浆β－ＥＰ含量与术中糖耐量降低和胰岛素分泌减少呈同步变化趋势，增加芬太尼剂量则使糖耐量稳定、β－ＥＰ释放相应减少。提示芬太尼剂量增加有助于改善手术应激性糖代谢异常。

The effects of fentanyl in different doses on the plasma β EP and glucose tolerance were evaluated during abdominal surgery. 24 patients were randomly allocated into two groups according to the dose of fentanyl, 10μg/kg or 15μg/kg. It was found that β EP levels were increased synchronously with the decrease in glucose tolerance and insulin release during operation. An increase of fentanyl could decrease β EP release and stabilize glucose tolerance indicating that increasing fentanyl dose may improve stress glucose abnormality.