CD44不同变异体在涎腺多形性腺瘤中的表达及意义

Expression of variants of CD44 molecules in polymorphic adenoma of salivary glands

目的探讨CD44不同变异体在涎腺多形性腺瘤中表达及意义。方法应用免疫组织化学方法检测30例涎腺多形性腺瘤CD44v3、CD44v6的表达。结果CD44v3在涎腺多形性腺瘤阳性（66．7％）表达，CD44v6在涎腺多形性腺瘤中呈强阳性表达（86．7％）。结论CD44v3、CD44v6在涎腺多形性腺瘤呈阳性表达，提示瘤细胞粘附力较强，可能是涎腺多形性腺瘤不易发生转移的原因。

Objective To investigate the expression of CD44v3 and CD44v6 in the polymorphic adenoma of salivary glands. Methods Using immunohistochemistry technology to detect the expression of CD44v3 and CD44v6 in 30 cases of polymorphic adenoma of salivary glands. Results The expression of CD44v3 was positive in 66.7 % cases within 30 paraffin-embedded sections,while CD44v6,86.7 % was positive. Conclusion The high expression of CD44v3 and CD44v6 maybe the reason of the low invasive ability and migration of polymorphic adenoma of salivary glands.