氢化泼尼松微胶囊缓释剂体外模拟释放试验研究

The imitation release test of extra-body on sustained-released injection of microcapsule hydro-cortisone

目的通过对氢化泼尼松微胶囊缓释剂进行体外模拟释放试验，了解微胶囊延长药物释放的作用。方法用高效液相色谱（HPLC）法检测药物降解结果，同时用显微镜及电镜观察微胶囊降解过程。结果释放试验开始的12～24h时，释放出药物量很低，随着微胶囊囊壁材料与PBS溶液接触时间延长（24～48h），并开始降解，释放的药物浓度也随着上升，在不同pH的PBS溶液中，由开始释放到达最高浓度一般需要3～5d并维持数天释放。结论氢化泼尼松微胶囊缓释剂可有效延长包裹药物释放时间。

Objective By extra-body imitation release test with prolongation,medicines action on sustainedreleased injection of hydro-cortisone microcapsule was understood. Methods Making use of HPLC method was inspected to result of medicinal lower and dissolution. At the same time, the dissolvent course of microcapsule wall was observed by microscope and electron microscope. Results The release test at beginning 12 -- 24 hours with release drugs measure was very lower-degree,along with the time more prolong in microcapsule substance to contact of PBS solution（24--48h） was began disintegrate. The release of medicinal concentration also accompany with rising, the rising different concentration PBS solution from starting up to the highest as to general need 3 - 5 days and keep releasing for several days. Conclusion Sustained-released injection of hydrocortisone microcapsule can be effectual action of prolongation released time in bind hydrocortisone.