草分枝杆菌注射液对尖锐湿疣的治疗分析

Effect of immunity function in condyloma acuminatum patients treated with differences of bacilli phlei injection after fulgurized

目的观察草分枝杆菌F．U．36注射液对尖锐湿疣电灼术后的临床疗效以及对机体免疫功能的影响。方法105例尖锐湿疣患者经电灼术后随机分为治疗组（草分枝杆菌，55例）和对照组（α-2b干扰素，50例），8周为1个疗程，观察两组疗效以及外周血T细胞亚群改变情况。结果治疗组与对照组治愈率分别为47．3％、24．0％（P〈0．05），复发率分别为11．5％、41．7％（P〈0．05）；治疗后两组CD3^＋、CD4^＋、CD4＋／CD8^＋均升高，而CD8^＋降低，经统计学分析，治疗后两组CD3^＋、CD4^＋、CD4^＋／CD8^＋比较差异有统计学意义（P〈0．05），而CD8^＋比较差异元统计学意义（P〉0．05）。结论草分枝杆菌注射液对防止尖锐湿疣复发具有一定作用，对患者免疫功能的提高优于α-2b干扰素。

Objective To observe the curative effect of condyloma acuminatum patients treated with differences of bacilli phlei injection after fulfurized and the effect of immunity function. Methods We compared curative effect and peripheral blood T lymphocyte subpopulation in the treatment group（55 cases, 8 weeks, prior and posttreatment with differences of bacilli phlei only） and the control group（50 cases, 8 weeks, prior and post-treatment with recombinant human interferon α-2b only）. Results Compared with the control group（24.0 %/41.7 % ）, the treatment group（47.3 %/11.5 % ） had advantage in the terms of cure rate and relapse rate（ P 〈 0.05）. CD3^＋ , CD4^＋ , CD4^＋/CD8^＋ increased and CD8^＋ decreased in two groups after treatment. CD3^＋ , CD4^＋ , CD4^＋/CD8^＋ were significantly increased in treatment group compared with the control group after treatment（P 〈 0.05）, but CD8^＋ had no obvious difference in two groups（P 〉 0.05）. Conclusion Differences of bacilli phlei injection can prevent relapse of condyloma acuminatum and increase immunity function of patients.