超氧化物歧化酶含量对肺癌病情的影响

Level of plasma superoxide dismutase and effect of superoxide dismntase on patients with lung cancer

目的探讨超氧化物歧化酶（SOD）在肺癌发病过程中的作用。方法采用黄嘌呤氧化酶法检测30例正常人及29例肺癌患者化疗前及化疗1、2、3个周期后血浆SOD值，并进行对比研究。结果肺癌组血浆SOD明显低于对照组（P〈0．01），化疗1、2个周期后SOD升高，但仍低于对照组（P〈0．01），化疗3个周期后SOD与对照组比较差异无统计学意义（P〉0．05），化疗前后鳞癌与腺癌问SOD值差异无统计学意义（P〉0．05），腺癌、鳞癌与鳞腺癌间SOD差异有统计学意义（P〈0．01）。各周期化疗后SOD差异有统计学意义（P〈0．01）。结论SOD与肺癌的发生、发展、治疗有关，可作为肺癌诊治的一个临床检测及疗效判定的指标。

Objective To detect the level of plasma superoxide dismutase（SOD） in patients with lung cancer and effect of chemotherapy（CGM ＋ CBP） on it,and to investigate the role of SOD in the development of lung cancer. Methods Xanthine oxidation enzyme was availabe to detect the level of plasma SOD in 30 cases of normal control subjects and 29 cases of patients with lung cancer before and after first, second, third cycle of chemotherapy. Resuits The levels of plasma SOD in lung cancer after chemotherapy were lower than those in the control group（P〈 0.01）. The level of plasma SOD in lung cancer after first and second chemo-cycle was higher than that before, but lower than that of control group（P 〈 0.01 ）, the differences between after third chemo-cycle and control group were not significant（ P 〉 0.05 ）. The differences in squamoun cell carcinoma and ad after were not significant （ P 〉 0.05 ）. The differences in squamoun cell carcinoma and ad before chemothrapy and and adenosquamoun carcinoma before chemotherapy and after were highly significant （P 〈 0. 01 ）. The differences in each chemo-cycle were highly significant （ P 〈 0.01 ）. Conclusion SOD played an important role in growth, regulation and treatment of lung cancer,and it might be a clinical index in lung cancer.