肾病综合征患儿白介素-8的检测及意义

Detection and clinical significance of interleukin-8 in the children with nephrotic syndrome

目的探讨肾病综合征（NS）患儿血清IL-8水平的变化及其临床意义。方法应用双抗夹心酶联免疫吸附（ELISA）法，检测45例NS患儿及35例同龄健康儿童血清IL-8的水平。结果NS急性期患儿血清IL-8为237．41ng／L，与健康儿对照组血清IL-823．19ng／L比较明显增高（P〈0．05）。NS急性期患儿血清白蛋白水平20．4g几，明显低于正常对照组水平45．8g／L（P〈0．05）。NS急性期患儿血清IL-8与血清白蛋白水平之间呈显著负相关（r=-0．607．P〈0．05）。结论IL-8与NS的发病密切相关，对血清IL-8水平的监测可作为NS患儿病情判断的参考指标。

Objective To study the level of serum interleukin-8 and its clinical significance in the children with nephrotic syndrome. Methods The level of serum interleukin-8 in the children with nephrotic syndrome（ n = 45） and normal controls group（ n = 35） were detected by enzyme linked immunosorbent assay. Results The level of serum interleukin-8 in children with nephrotic syndrome at acute stage were significantly higher than those in nephrotic syndrome at catabasis stage and normal controls group（P 〈 0.05）. The level of serum albumin in children with nephrotic syndrome at acute stage and catabasis stage were significantly lower than that in normal controls group（P 〈 0.05）, the level of serum albumin in children with nephrotic syndrome at acute stage were significantly lower than that in catabasis stage（ P 〈 0.05 ）. There was a negative correlation between the level of interleukin 8 and the level of serum albumin in children with nephrotic syndrome at acute stage（ r = -0. 607, P 〈 0.05 ）. Conclusion The invasion of nephrotic syndrome maybe were related to interleukin-8.