化疗药对病毒瘤苗免疫效果的影响

AFFECTION OF DIFFERENT CHEMOTHERAPEUTIC DRUGS ON IMMUNOCOMPETENCE OF VIRAL ONCOLYSATE

不同化疗药作用过的肿瘤细胞，经病毒感染后制成瘤苗的免疫效果明显不同。环磷酰胺和地塞米松能增强肿瘤细胞的抗原性，病毒感染后制备的瘤苗免疫力也随之增强，而阿糖胞苷对肿瘤细胞无影响，处理过的肿瘤细胞经病毒感染后制备的瘤苗抗原性反而降低。环磷酰胺预先处理荷瘤小鼠腹腔的肿瘤细胞，可去除Ｔｓ细胞的作用，保持新城疫病毒－瘤苗的免疫效果，提高受攻击小鼠的存活率。

The viral oncolysates were prepared by using P388 tumor cells that treated with different chemotherapeutic drugs, such as cyclophosphomide, dexamethasone and cytarabine, their immunogenicity was different Cyclophosphomide and dexametleasone could raise antigenicity of P388 tumor cells and strengthen the immunocompetence of the viral oncolysates prepared by P388. By contrast the viral oncolysates treated with cytarabine had decreased immunocompetence Cyclophosphomide could inhibit activity of Ts cells in mice, raised immunocompetence of the viral oncolysates and increased survival rate of the mice challenged by tumor cells