上海地区成年人胃食管反流病流行病学调查 Ⅱ: 症状与胃食管反流病的关系

EPIDEMIOLOGY OF GASTROESOPHAGEAL REFLUX DISEASE IN SHANGHAI ADULTS PART Ⅱ:CORRELATION OF SYMPTOMS AND GASTROESOPHAGEAL REFLUX DISEASE

在对上海地区成年人胃食管反流症状流行病学调查的基础上，对有烧心、反酸及反食等胃食管反流症状者，按症状轻重记分，根据总分将有症状者分为低分组（６～９分）、中分组（１０～１２分）及高分组（≥１３分），并按随机原则分别抽取２０、１０及１０例，进行２４ｈ食管ｐＨ监测及胃镜检查。结果发现：各有症状组异常胃食管反流（ＡＧＥＲ）及胃食管反流病（ＧＯＲＤ）发生率均明显高于对照组（Ｐ＜０．０５），高分组反流性食管炎（ＲＥ）发生率亦明显高于对照组（Ｐ＜０．０５），但各症状组间无明显差异（Ｐ＞０．０５）。４６．６７％ＡＧＥＲ患者存在ＲＥ，７７．７８％ＲＥ患者证实有ＡＧＥＲ。ＡＧＥＲ、ＲＥ及ＧＯＲＤ患病率分别为３．５８％、２．２７％及２．８６％。

On the basis of epidemiology study of gastroesophageal reflux symptoms in Shanghai adults, patients with heartburn, regurgitation and/or food reflux were subdivided into three groups according to the severity of the symptoms, and 20 cases were randomly selected in lower score group(6￣9 score),10 in moderate score group(10￣12 score) and 10 in high score group(≥13 score) respectively to investigate 24 hour esophageal pH monitoring and upper gastrointestinal endoscopy. The results showed that the prevalence of abnormal gastroesophageal reflux(AGER) and gastroesophageal reflux disease (GORD) in each of the three groups was much higher than that in control( P <0 05), and the prevalence of reflux esophagitis(RE) was also much higher than that in control( P <0 05). But there were no significant differences among these three groups. 46 67% of patients with AGER had RE and 77 78% with RE had AGER. Besides, the prevalences of AGER, RE and GORD in Shanghai adults were 3 58%, 2 27% and 2 86% respectively. In conclusion, GORD is not uncommon in Shanghai. This information is of great importance to doctors when evaluating patients with regrugitation and/or heartburn.