芳香稠环取代酰氯的合成

SYNTHESIS OF CARBONYL CHLORIDES SUBSTITUTED WITH AROMATIC DENSE RING

芳香稠环取代酰氯的合成胡文祥恽榴红张连锋（国防科工委军事医药研究发展中心，北京１００１０１；军事医学科学院毒物药物研究所，北京１００８５０）许多高效药物和激素用量甚少，分布全身代谢后血药浓度更低，并且它们又往往不含强烈的发色基团，因此在药代...

Carbonyl chlorides substituted with aromatic dense ring are chemically active and their fluorescent quantum yields are usually high and they may be used as fluorescent probes for detection of many compounds. Studies on their synthesis and structure activity relationship are very important in the micro or supermicro detection of drugs and toxicants containing hydroxy groups. Therefore, the probes may find wide application in the fine chemical engineering and pharmaceutical industry. Three new fluorescent probes: β (9 anthracene) acrylonyl chloride, β (9 anthracene) propionyl chloride and β (1 pyrene) acrylonyl chloride were synthesized by the reaction between the corresponding acid and thionyl chloride. 1 Pyrenecarboxaldehyde synthesized by using pyrene and N formyl N methylaniline with phosphorus oxychloride as catalyst, was allowed to react with malonic acid to produce β (1 pyrene) acrylic acid for the last mentioned acid chloride.