升麻酰胺及其类似物的合成

STUDIES ON SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF CIMICIFUGAMIDE FROM CIMICIFUGA DAHURICA , AND ITS ANALOGUES

升麻酰胺是从兴安升麻（Ｃｉｍｉｃｉｆｕｇａｄａｈｕｒｉｃａ）根茎中分到的新天然产物，本文经７步反应完成了该化合物的全合成，总收率为３１％，三氟乙酰氧基用作Ｃ１的离去基团，其结构经光谱分析和元素分析证实与天然物相一致。此外，还报道其７个类似物的合成及初步的抗肿瘤活性实验结果。

The total synthesis of cimicifugamide, a new natural compound isolated from the roots of Cimicifuga dahurica , was accomplished by a reaction sequence of seven steps in an overall yield of 31%. Trifluoroacetoxy was used as leaving group at the anomeric carbon. The target product was characterized by IR, MS, 1HNMR, 13 CNMR and elemental analysis. In addition, seven analogues were synthesized and their preliminary pharmacological activities were tested.