头序木叶中三萜化学成分的研究

STUDIES ON TRITERPENOIDS AND THEIR GLYCOSIDES FROM ARALIA DASYPHYLLA MIQ

从头序木（ＡｒａｌｉａｄａｓｙｐｈｙｌａＭｉｑ）叶中分离到６个三萜化合物，用化学方法和波谱（ＵＶ，ＩＲ，ＭＳ，１ＨＮＭＲ，１３ＣＮＭＲ，１３ＣＤＥＰＴ，ＨＭＱＣ，ＨＭＢＣ）分析，确定其中４种化合物的结构，分别为齐墩果酸（Ｉ），１６β羟基１８βＨ齐墩果酸（Ｉ），齐墩果酸２８ＯβＤ吡喃葡萄糖甙（ＩＩ）和１６β羟基１８βＨ齐墩果酸２８ＯβＤ吡喃葡萄糖甙（ＩＶ）。用ＮＯＥＳＹ谱确定化合物Ｉ的立体构型。以上４个化合物均为首次从该植物中分离到，化合物ＩＶ为新化合物。

The structures of two triterpenoids and their glycosides were isolated from Aralia dasyphylla Miq Their structures have been identified to be oleanoic acid(I), 16β hydroxy 18β H oleanoic acid(II), oleanoic acid 28 O β D glucopyranoside(III) and 16β hydroxy 18β H oleanoic acid 28 O β D glucopyranoside(IV), respectively, mainly through interpretation of UV, IR, MS, 1H and 13 CNMR, DEPT, HMQC and HMBC spectra data The stereochemistry of II has been confirmed by NOESY Pharmacological experiments showed that the total saponins exerted preventative effect on CCl 4 induced liver injury of male mice and hypoglycemic effect on a model of alloxan induced diabetes in rats