摘要
以泊洛沙姆１８８或聚乙烯吡咯烷酮为载体，分别应用熔融—溶剂法或溶剂法制备了环孢素Ａ—泊洛沙姆、环孢素Ａ—聚乙烯吡咯烷酮固体分散物，其比例为１０∶９０～９０∶１０。通过粉末Ｘ射线衍射、热台显微镜、差示扫描量热法等研究其物理化学性质的变化，为药物处方前的研究提供可靠的科学依据。
In this paper, poloxamer and PVP were used as carriers. CyA poloxamer and CyA PVP solid dispersions were prepared using the melting solvent method or solvent method, respectively. The percentage compositions of the solid dispersions ranged from 10∶90 to 90∶10. Hot stage microscopy, powder X ray diffraction and differential scanning calorimetry were used to examine the physical chemical characteristics of the solid dispersions to provide some reliable and scientific basis for preformulation of CyA.
出处
《药学学报》
CAS
CSCD
北大核心
1997年第10期777-781,共5页
Acta Pharmaceutica Sinica
