布洛芬糖浆剂药动学及相对生物利用度

Pharmacokinetics and relative bioavailability of ibuprofen syrup

目的：测定布洛芬糖浆剂的药动学及相对生物利用度。方法：８名健康男性志愿者单剂量随机交叉ｐｏ４００ｍｇ布洛芬后，采用ＨＰＬＣ测定血浆药物浓度。结果：口服糖浆剂及片剂后血药浓度达峰时间分别为（０．８６±０．３０）ｈ和（１．７８±０．３４）ｈ，峰浓度分别为（４８．９±９．７１）μｇ·ｍｌ－１和（４４．２±８．２３）μｇ·ｍｌ－１，药时曲线下面积分别为（１７５．１±３１．９）μｇ·ｈ·ｍｌ－１和（１７８．６±２３．２）μｇ·ｈ·ｍｌ－１。结论：统计分析表明，糖浆剂较片剂达峰时间短，吸收快。布洛芬糖浆剂相对生物利用度为（９８．３±１４．５）％。

OBJECTIVE: To determine the pharmacokinetics and relative bioavailability of ibuprofen syrup. METHODS: The drug concentration in plasma was assayed by HPLC method after administration of a single oral dose of 400 mg ibuprofen to each of 8 healthy male volunteers. RESULTS: The peak levels (t p) in plasma averaged (48.9± 9.71 )μg·ml -1 and (44.2±8.23)μg·ml -1 at (0.86±0.30)h and (1.78±0.34)h, and the areas under the drug concentration curves (AUC) were (175.1±31.9)μg·h·ml -1 and (178.6±23.2)μg·h·ml -1 for ibuprofen syrup and tablets, respectively. CONCLUSION: The result of statistical analysis showed that the syrup could reach peak level faster than tablets.