低出生体重影响肾小球滤过率的荟萃分析

Low birth weight influences glomerular filtration rate:a meta analysis

目的研究比较低出生体重对肾小球滤过率的远期影响。方法以"birth weight"、"creatinine clearance"、"glomerular filtration rate"、"renal function"对Pubmed所有文献进行检索。按筛选标准共有7篇文献入选。使用Revman4.2进行统计分析。结果低出生体重者肾小球滤过率较低,约比正常出生体重者降低4ml/(min·1.73m^2),剔除以儿童为观察对象的研究后,结果仍显示低出生体重者肾小球滤过率较低,约比正常出生体重者降低3～4ml/(min·1.73m^2)。结论低出生体重者在儿童期以后虽然肾小球滤过率在正常范围,但已比正常出生体重者有降低。

Objective To study the effect of low birth weight on glomerular filtration rate （GFR） in adulthood. Methods We searched the database PubMed for related literature by using the keywords birth weight, creatinine clearance, glomerular filtration rate and renal function. According to our study purposes, 7 clinical study reports were included and analyzed. Revman 4.2 was used for data analysis. Results GFR of individuals with a low birth weight was normal, however, their GFR was 4ml/（min · 1.73m^2） lower than that of those with a normal birth weight. This finding is still evident after we exclude 2 studies measured in childhood. Conclusion GFR of adult individuals with a low birth weight is in the normal range, but is lower than that of those with a normal birth weight.