摘要
第二信使、基因表达调节和神经元可塑性等细胞内信号通路异常均可能参与双相障碍的发病机制。心境稳定剂可能通过调节细胞内信号系统而保护神经元、稳定心境。
出处
《国际精神病学杂志》
2008年第2期119-122,共4页
Journal Of International Psychiatry
参考文献9
-
1Manji HK, Quiroz JA, Payne JL, et al. The neurobiology of bipolar disorder. World Psychiatry, 2003; 2 (3) : 136-146.
-
2Frey BN, Fonseca MM, Machado-Vieira R, et al. Neuropatological and neurochemical abnormalities in bipolar disorder. Rev Bras Psiquiatr. 2004; 26 (3): 180-118.
-
3Alda M, Keller D, Grof E, et al. Is lithium response related to G (s) alpha levels in transformed lymphoblasts from subjects with bipolar disorder? J Affect disorder, 2001; 65 (2): 117- 122.
-
4Chang A, Li PP, Warsh JJ. Altered cAMP-dependent protein kinase subunit immunolabeling in postmortmem brain from patients with bipolar affective disorder. J Neurochem. 2003; 84 (4): 781-791.
-
5Montezinho LP, Castro MM, duarte CB, et al. The interaction between dopamine D2-like and beta-adrenergic receptors in the prefrontal cortex is altered by mood-stabilizing agents. J Neurochem. 2006; 96 (5): 1336-1348.
-
6Soares JC, Dippold CS, Wells KF, et al. Increased platelet membrane phosphatidyhnositol-4, 5-bisphosphate in drug-free depressed bipolar patients. Neurosci Lett. 2001 ; 299 (1-2) : 150-152.
-
7Brunello N. Mood stabilizers: protecting thd mood... protecting thd brain. J Affect Disord. 2004; 79 (Suppl 1) : S15-20.
-
8Bebchuk JM, Arfken CL, Dolan-Mar JS, et al. A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania. Arch Gen Psychiatry, 2000; 57 (1): 95-97.
-
9Cunha AB, Frey BN, Andreazza AC, et al. Serum brain-derived neurotrophic factor is decreased in biploar disorder during depressive and manic episodes. Neurosci Lett. 2006; 398 (3): 215-219.
同被引文献48
-
1孙万春,朱兴族.基底神经节中多巴胺和腺苷受体二聚化及其药理学意义[J].生命科学,2004,16(4):193-199. 被引量:3
-
2张红霞,徐俊冕.双相情感障碍研究进展[J].世界临床药物,2005,26(3):159-163. 被引量:3
-
3刘大志,朱兴族.腺苷在脑缺血过程中的双重作用[J].生命科学,2005,17(3):227-230. 被引量:11
-
4刘卫英,邓元江,彭楚湘,周平,梁伟雄.穴位埋线对实验性癫痫大鼠大脑皮质氨基酸类神经递质的影响[J].中医研究,2005,18(12):6-9. 被引量:21
-
5REZVANI M E, ROOHBAKHSH A, ALLAHTAVAKOLIM, et al. Anticonvulsant effect of aqueous extract ofValeriana officinalis in amygdala-kindled rats : possibleinvolvement of adenosine [ J]. Journal of Ethnopharmacol.2010. 127(2): 313-318.
-
6REBOLA N, RODRIGUES R J, LOPES L V,et al.Adenosine Al and A2a receptors are co-expressed inpyramidal neurons and co-localized in glutamatergic nerveterminals of the rat hippocampus [J]. Neuroscience. 2005.133(1): 79-83.
-
7OKADAM,NUTTDJ, MURAKAMIT, etal.Adenosinereceptor subtypes modulate two major functional pathwaysfor hippocampal serotonin release [J]. The Journal ofNeuroscience. 2001,21 (2) : 628-640.
-
8COUSINS D A, BUTTS K, YOUNG A H. The role ofdopamine in bipolar disorder [J]. Bipolar Disord, 2009,11(8): 787-806.
-
9DUNWIDDIE T V,MASINO S A. The role and regulation ofadenosine in the central nervous system [J]. Annu RevNeurosci, 2001, 15(2): 31-55.
-
10BURNSTOCK G Physiology and pathophysiology ofpurinergic neurotransmission [J]. Physiol Rev,2007,87 (2):659-797.
二级引证文献4
-
1陈红梅,陈景旭,陈大春,周双桨,张立刚,王璇,田成华,王绍礼.双相情感障碍血清尿酸水平研究[J].中国神经精神疾病杂志,2016,42(1):29-33. 被引量:36
-
2陈红梅,田成华,陈景旭,王璇,周双桨,王绍礼.双相障碍躁狂发作治疗前后血清尿酸水平分析[J].国际精神病学杂志,2016,43(2):239-242. 被引量:7
-
3郑莉明,朱艳芳,敖海清,徐志伟.双相障碍的阴阳转化病机内涵及其指导意义[J].辽宁中医杂志,2017,44(3):506-508. 被引量:6
-
4贡永宁,王冲,孙连锋,胡亚凯.奥氮平与碳酸锂对双相情感障碍患者躁狂症状、血清尿酸水平的影响及安全性比较[J].国际精神病学杂志,2018,45(4):655-657. 被引量:37
-
1石胜良,陈仕检,刘唐威.卒中后神经病理学与神经可塑性机制的分析[J].中国脑血管病杂志,2010,7(1):46-48. 被引量:2
-
2翟飞,刘巨源,王长虹.神经营养因子与抑郁症[J].临床心身疾病杂志,2015,21(2):112-115. 被引量:1
-
3李育臣,董玉娟,王建茹,王冰.银杏叶提取物对脑缺血大鼠脑源性神经营养因子的影响[J].中风与神经疾病杂志,2005,22(1):54-56. 被引量:14
-
4周志才,张赛.神经干细胞脑内移植的相关研究及临床应用[J].临床荟萃,2009,24(17):1551-1552.
-
5王红丽,李继涛,苏允爱,司天梅.BDNF-TrkB信号系统在精神分裂症发病及治疗中的作用[J].国际精神病学杂志,2017,44(2):200-203. 被引量:10
-
6高磊,王茂斌.脑的可塑性与卒中康复[J].国外医学(脑血管疾病分册),2000,8(6):368-371. 被引量:9
-
7赵路清,王鲁宁.胰岛素及胰岛素-胰岛素受体信号通路异常与阿尔茨海默病研究进展[J].中华老年医学杂志,2007,26(2):152-154. 被引量:3
-
8邬剑军,任惠民,蒋雨平.胰岛素对1-甲基-4-苯基吡啶离子诱导的嗜铬细胞瘤细胞损伤的保护[J].中华医学杂志,2008,88(5):342-347.
-
9汪建华,王学峰.Tau蛋白与癫痫[J].实用医院临床杂志,2004,1(3):77-79.
-
10张茴燕,殷小平.一氧化碳对TLR4/NF-κB信号通路影响的研究进展[J].神经损伤与功能重建,2017,12(1):48-51. 被引量:9