谷氨酰胺和生长激素联合应用在疾病治疗中的作用

Combined application of glutamine and growth hormone in clinic

谷氨酰胺和生长激素是人体两种主要的免疫营养要素,谷氨酰胺是一种重要的营养底物,而生长激素是一种促合成激素。近年来许多研究发现,谷氨酰胺和生长激素具有促进蛋白质合成、保护肠黏膜屏障及增强机体免疫功能等作用,两者联合应用于短肠综合征、肝硬化、烧伤、肿瘤等患者的营养支持时具有协同作用。本文对谷氨酰胺和生长激素联合应用在临床疾病治疗中的作用作一综述。

Glutamine（Gin） and growth hormone are all main essential immunonutrition elements. Gin is an im- portant nutrition element and growth hormone is a hormone promoting synthesis. Recently, many researches discovered that combined application of Gin and recombinant human growth hormone（rhGH） was beneficial to the systemic protein synthesis, immune function and could prevent deterioration of gut permeability, preserve mucosal structure. Cooperation effect was discovered between Gin and rhGH in treatment of short bowel syndrome, hepatic cirrhosis, empyrosis, tumor and other diseases. This article reviewed the effects of combined treatment with glutamine and growth hormone in clinic.