摘要
非酒精性脂肪性肝病的发病机制至今尚不十分清楚.近年来众多研究表明,本病存在肝细胞凋亡的异常,说明肝细胞凋亡与本病的发生密切相关.调控细胞凋亡的机制可分正向/负向两个方面的调控因素.本文就近几年在非酒精性脂肪性肝病肝细胞凋亡调控机制方面的研究进展作一综述.
The pathogenic mechanism of nonalcoholic fatty liver disease (NAFLD) still remains unclear. In recent years, many studies indicate that abnormal hepatocyte apoptosis exists in NAFLD, confirming the close relationship between NAFLD and hepatocyte apoptosis. The regulation of cell apoptosis includes two: positive or negative. In this paper, we review the research advances in the regulation of hepatocyte apoptosis during the pathogenesis of NAFLD.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第12期1327-1331,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30672635
上海市教委重点学科建设资助项目
No.Y0302~~
关键词
非酒精性脂肪性肝病
细胞凋亡
肝细胞
Nonalcoholic fatty liver disease
Cell apoptosis
Liver cell