早期胚胎发育与肿瘤发生的相关性研究进展

Research progress in correlation between early embryo development and tumorigenesis

随着对发育生物学领域认识的不断深入,研究者发现早期胚胎发育与肿瘤发生的生物学行为存在相似之处,并且胚胎与肿瘤之间存在着重要的相互作用,为进一步从发育生物学角度去认识肿瘤,寻求治疗肿瘤开拓了新的思路.本文主要从发育生物学角度阐述肿瘤的胚胎源性,早期胚胎发育与肿瘤发生在基因、蛋白、代谢水平和其它重要生物学行为方面的相似性,以及两者之间的相互作用.

With the increased cognition in developmental biology, researchers.have discovered the similarity of biological behaviors between early embryo development and tumorigenesis, as well as the important interaction between tumors and embryos. Therefore, it enlightens us to study tumors from the view of developmental biology, which may provide a new clue for tumor therapy. In this article, we review in detail＇the embryonic＇origin of tumors, the similarity between early embryo development and tumorigenesis at the level Of gene and protein expression, their important biological behaviors, and moreover, the interaction between tumors and embryos from the angle of developmental biology.