老年性黄斑变性的吲哚青绿和荧光素眼底血管造影

Indocyanine green and fundus fluorescein angiography in age-related macular

目的探讨眼底荧光素血管造影（fundus fluorescein angiography，FFA）和吲哚青绿血管造影（indocyanine green angiography，ICGA）在老年性黄斑变性（age—related macular degeneration，AMD）患者中的临床应用。方法对AMD患者375例742只眼的FFA和ICGA检查资料进行分析总结。结果在所有患者中，萎缩型504只眼（67．9％），渗出型238只眼（32．1％）。在同步进行FFA和ICGA检查的渗出型AMD 93只眼中，FFA检查发现典型性CNV 14只眼（15．1％），隐匿性CNV 79只眼（84．9％）；ICGA检查发现边界清楚的CNV 48只眼（51．6％），两者相比差异具有统计学意义（χ^2=27．97，P〈0．01）。ICGA检查发现CNV的供养血管6只眼（6．5％），均位于中心凹旁或中心凹外。在发现边界清楚CNV的48只眼中，中心凹下CNV 29只眼（60．4％），中心凹旁CNV 12只眼（25．0％），中心凹外CNV7只眼（14．6％）。结论与FFA相比，ICGA可以更加准确地显示CNV，发现CNV的供养血管，对AMD的临床诊断和治疗具有更重要的指导意义。

Objective To investigate the clinical application of fundus fluorescein angiography（FFA） and indocyanine green angiography （ICGA）in age-related macular degeneration （AMD）. Methods The FFA and ICGA data of 742 eyes of 375 AMD patients were analyzed and summarized.Results In all patients, 504 eyes （67.9%） were atrophic AMD and 238 eyes （32.1%）were exudative AMD. Of 93 exudative AMD eyes simultaneously performed FFA and ICGA, 14 eyes（ 15.1% ）with classic CNV and 79 eyes（ 84.9% ） with occult CNV were found by FFA, 48 eyes （51.6%）with clear boundary CNV were found by ICGA,and there was significantly statistical difference （ χ^2 = 27.97, P 〈 0.01 ）between them. Feeder vessels of CNV were found in 6 eyes（ 6.5% ）by ICGA, and all were juxtafoveal and extrafoveal. Of 48 eyes with clear boundary CNV, 29 eyes （60.4%）with subfoveal CNV, 12 eyes （25.0%）with juxtafoveal CNV and 7 eyes （14.6%）with extrafoveal CNV. Conclusions Compared with FFA, ICGA may show CNV more clearly and the feeder vessel of CNV, and is more important to the clinical diagnosis and treatment of AMD.