单疱病毒性角膜内皮炎的诊治探讨

Diagnosis and Therapy oF Herpes Simplex Virus Endothelitis

目的探讨单疱病毒性角膜内皮炎的临床表现和治疗原则，尤其是激素类药物的应用方法。方法临床收集22例单疱病毒性角膜内皮炎的患者分为盘状型、弥漫型和线状型，明确诊断后应用抗病毒制剂和高浓度激素治疗，部分重症的弥漫型和全部线状型的患者全身给予抗病毒药和激素药物，观察视力和角膜后KP消退的时间。结果应用上述方法治疗后盘状型、弥漫型和线状型视力恢复时间分别为：（10．17±2．44）d，（16．50±3．16）d，（27．00±4．24）d，KP消退的时间为（15．17±2．55）d．（23．25±4．20）d，（37．50±4．95）d。结论局部足量的抗病毒制剂和激素治疗单疱病毒角膜内皮炎是非常有效的；单疱病毒线状角膜内皮炎是最严重的类型，需要给予全身的抗病毒和激素类药物，应用时间要长于其他类型。

Objective To investigate the clinical finding and therapy in Herpes Simplex Virus endothel iris, especially application of hormone. Methods 22 cases HSV endothelitis were divided into 3 groups, that were disciform, diFFuse and linear according to the clinical appearance. Antiviral agents and high-dose Corticosteroids were used. General Antiviral agents and Corticosteroids were applied in several diffuse and all linear cases to observe the vision and KP disappear were observed. Results The time of vision recovery was （ 10.17± 2.44）, （ 16.50± 3. 16）, （27.00± 4.24） days in disciform, diffuse and linear groups respectively. The time of the KP disappearing as （15.17 ± 2.55）, （23.25 ± 4.20）, （37.50 ± 4.95）days. Conclusion The topically use of enough antiviral agents and high-dose corticosteroids is effective in HSV endothelitis. HSV linear endothelitis is the most severe and need to use systemically antiviral agents and corticosteroids and more time.