新型N,N′-二(邻氧乙酸)苄叉丙二胺合铜(II)和镍(Ⅱ)及N-(邻氧乙酸)苄叉丙二胺合铜(Ⅱ)的合成、晶体结构及抑菌活性

Synthesis,Crystal Structure and Antibacterial Activity of Two Novel Complexes of N,N′-Bis(o-oxy-acetate)benzylpropylenediamine with Cu(Ⅱ) and Ni(Ⅱ) and a Complex N-(o-oxy-acetate) benzylpropylenediamine with Cu(Ⅱ)

在乙醇和水的混合溶液中，将N，N′-二（邻氧乙酸）苄又丙二胺（1）与氯化铜反应，获得配合物Cu（Ⅱ）L^1·H2O·0．25CH3CH2OH（2）[L^1：N，N′-二（邻氧乙酸）苄叉丙二胺]；当将反应混合溶液的pH值调至8～9，获得cu（Ⅱ）ClL^2·3H2O（3）[L^2=N-（邻氧乙酸）苄又丙二胺]；将N，N′-二（邻氧乙酸）苄叉丙二胺（1）与氯化镍反应，获得配合物Ni（Ⅱ）L^1·2．75H2O（4）-用元素分析、^1H NMR和IR谱等方法对所合成的化合物1和配合物2～4进行了表征，并测定了配合物2～4的晶体结构．在配合物2中，铜原子为六配位[CuN2O4]，在配合物3中，铜原子为六配位[CuN2O3Cl]，在配合物4中，镍原子为六配位[NiN2O4]，三个配合物均为畸变八面体结构,抑菌活性大小的顺序：配合物3〉配合物2〉化合物1．

Complex Cu（ Ⅱ ）L^1 · H2O · 0.25CH3CH2OH（2） [L^1 =N,N′-bis（o-oxy-acetate） benzylpro-pylenediamine （1） ] was synthesized via the reactions between compound 1 and Cu （ Ⅱ ） dichloride in the solvents of water and ethanol, and Cu （ Ⅱ ） ClL^2 · 3 H2O （ 3 ） [ L^2 = N- （o-oxy-acetate） benzylpropylenediamine ] was prepared via the reaction between compound 1 and Cu（ Ⅱ ） dichloride in the solvents of water and ethanol （pH = 8 -9）. Complex Ni（ Ⅱ ）L^1 · 2.75H2O（4） was also synthesized by the reactions between the compounds 1 and Ni （ Ⅱ ） dichloride in water. Compounds 1-4 were characterized by elemental analysis, ^1H NMR, FTIR spectroscopy and single crystal X-ray diffraction analysis. There are one molecule （hostmolecule）, one water molecule（guestmolecule） and quarter ethanol molecule in one asymmetric unit of complex 2, the Cu（ Ⅱ ） atom exhibits a distorted octahedral geometry. There are one molecule（hostmolecule） and three water molecules in each unit of complex 3, the Cu （ Ⅱ ） atom exhibits a distorted octahedral geometry. In the asymmetric unit of complex 4, the Ni （ Ⅱ ） atom also exhibits a distorted octahedral geometry. Complexes 2 and 3 exhibit good antibacterial properties, while the antibacterial properties decrease in the following order： complex 3 〉 complex 2 〉 compound 1.