摘要
在乙醇和水的混合溶液中,将N,N′-二(邻氧乙酸)苄又丙二胺(1)与氯化铜反应,获得配合物Cu(Ⅱ)L^1·H2O·0.25CH3CH2OH(2)[L^1:N,N′-二(邻氧乙酸)苄叉丙二胺];当将反应混合溶液的pH值调至8~9,获得cu(Ⅱ)ClL^2·3H2O(3)[L^2=N-(邻氧乙酸)苄又丙二胺];将N,N′-二(邻氧乙酸)苄叉丙二胺(1)与氯化镍反应,获得配合物Ni(Ⅱ)L^1·2.75H2O(4)-用元素分析、^1H NMR和IR谱等方法对所合成的化合物1和配合物2~4进行了表征,并测定了配合物2~4的晶体结构.在配合物2中,铜原子为六配位[CuN2O4],在配合物3中,铜原子为六配位[CuN2O3Cl],在配合物4中,镍原子为六配位[NiN2O4],三个配合物均为畸变八面体结构,抑菌活性大小的顺序:配合物3〉配合物2〉化合物1.
Complex Cu( Ⅱ )L^1 · H2O · 0.25CH3CH2OH(2) [L^1 =N,N′-bis(o-oxy-acetate) benzylpro-pylenediamine (1) ] was synthesized via the reactions between compound 1 and Cu ( Ⅱ ) dichloride in the solvents of water and ethanol, and Cu ( Ⅱ ) ClL^2 · 3 H2O ( 3 ) [ L^2 = N- (o-oxy-acetate) benzylpropylenediamine ] was prepared via the reaction between compound 1 and Cu( Ⅱ ) dichloride in the solvents of water and ethanol (pH = 8 -9). Complex Ni( Ⅱ )L^1 · 2.75H2O(4) was also synthesized by the reactions between the compounds 1 and Ni ( Ⅱ ) dichloride in water. Compounds 1-4 were characterized by elemental analysis, ^1H NMR, FTIR spectroscopy and single crystal X-ray diffraction analysis. There are one molecule (hostmolecule), one water molecule(guestmolecule) and quarter ethanol molecule in one asymmetric unit of complex 2, the Cu( Ⅱ ) atom exhibits a distorted octahedral geometry. There are one molecule(hostmolecule) and three water molecules in each unit of complex 3, the Cu ( Ⅱ ) atom exhibits a distorted octahedral geometry. In the asymmetric unit of complex 4, the Ni ( Ⅱ ) atom also exhibits a distorted octahedral geometry. Complexes 2 and 3 exhibit good antibacterial properties, while the antibacterial properties decrease in the following order: complex 3 〉 complex 2 〉 compound 1.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2008年第5期876-881,共6页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:20773021)资助
关键词
邻氧乙酸苯甲醛
铜(Ⅱ)配合物
晶体结构
抑菌活性
o-Oxy-acetate-benzaldehyde
Cu ( Ⅱ ) complex
Crystal structure
Antibacterial activity