安迪尔胶囊预防缓慢性心律失常的实验研究

Empirical Study of Capsule An-di-er(安迪尔胶囊) on Slow Arrhythmic Prevention

目的:探讨安迪尔胶囊预防缓慢性心律失常的作用。方法:将50只大鼠随机分为模型组、阳性对照组(心宝丸)、安迪尔低、中、高剂量组,灌胃给药,连续7天。末次用药2小时后,腹腔注射普萘洛尔5mg/kg,记录注后即刻及2、5、10、20min的心率。结果:安迪尔中剂量组下降幅度小于模型组(P<0·05),安迪尔高剂量组下降幅度明显小于模型组(P<0·01)。结论:安迪尔胶囊可能具有激活β肾上腺素受体及促进儿茶酚胺释放的作用。

Objective： To approach the effect of Capsule An-di-er on slow arrhythmic prevention. Method： 50 rats were divided into 5 groups randomly, which were model group, positive control group （Pellet Xinbao）,Capsule An-di-er low dose group, midium dose group and high dose group. Administer by intragastric administration for 7 days. After administering 2 hours last time, Propranolol according to 5mg/kg was injected by intraperitoneal injection. Then record the heart rate at 2, 5, 10 and 20min. Result ： The heart rate in Capsule An-di-er midium dose group decreased less than in model group （ P 〈 0. 05 ）, and that in Capsule An-di-er high dose group decreased less than in model group remarkably （P 〈 0.01 ）. Conclusion ： Capsule An-di-er may have the effect of activating adrenoreceptor and enhancing catechol amine to deliver.