摘要
目的探讨单核细胞趋化蛋白1(MCP-1)启动子区-2518A/G基因多态性与冠状动脉(冠脉)粥样硬化病变进程及经皮冠脉腔内成形术(PCI)后再狭窄的相关性。方法对276例接受PCI并进行冠脉造影随访的患者,采用PCR—RFLP方法进行MCP-1—2518A/G多态性检测;按冠脉造影结果分为再狭窄组(113例)和无再狭窄组(163例),判定冠脉血管病变及再狭窄与MCP-1—2518A/G多态性的相关性。结果MCP-1—2518A/G基因型频率为:AA纯合子21.0%,GG纯合子34.1%,AG杂合子44.9%,3种基因型血管病变支数和血管平均狭窄程度,差异均无统计学意义(P〉0.05)。再狭窄组中AA、AG和GG基因型频率分别为23.9%、40.7%和35.4%,无再狭窄组分别为19.0%、47.9%和33.1%,差异无统计学意义(P=0.446)。再狭窄组中-2518A和G等位基因频率分别为44.2%和55.8%,无再狭窄组分别为42.9%和57.1%,差异无统计学意义(P=0.761)。结论冠脉粥样硬化进程及PCI术后再狭窄可能与MCP-1—2518A/G基因多态性无相关性。
Objective To investigate the association of monocyte chemoattractant protein-1 (MCP-1) promoter -2518A/G gene polymorphism with coronary lesions and in-stent restenosis in Tianjin Chinese population. Methods Two hundred and seventy six patients who underwent percutaneous coronary intervention (PCI) and coronary angiography during follow-up were enrolled in the study. The MCP-1 gene promoter polymorphism at position -2518 was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results The frequencies of three genotypes of MCP-1 -2518A/G polymorphism were 21.0% AA, 34.1% GG, 44.9% AG, respectively. There were no statistical differences in the number and the mean degree of stenosis vessels before PCI among 3 genotype groups (all P)0.05). 113 cases developed in-stem restenosis and 163 cases were free from restenosis. In restenosis group, the AA, AG and GG genotype frequencies were 23.9%, 40.7%, 35.4%, against 19.0%, 47.9% and 33. 1% in non- restenosis group (P=0.446). The frequencies of-2518A and G allele were 44.2%, 55.8% in restenosis group versus 42. 9%, 57.1% in non-restenosis group(P=0. 761). Conclusions The polymorphism of MCP-1-2518 A/G gene may be associated with neither atherosclerosis nor the in-stem restenosis.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2008年第5期321-324,共4页
Chinese Journal of Geriatrics
基金
天津市重点科技发展攻关项目(05YFSZSF02700)