血清PSA与前列腺癌骨转移的关系

The diagnostic value of serum PSA in patients with bone metastasis of prostatic cancer.

目的:探讨血清前列腺特异抗原(PSA)预测前列腺癌骨转移的价值。方法:以全身核素骨显像为金标准,回顾性分析放免法测定的58例前列腺癌骨转移和63例非骨转移患者血清PSA水平与骨转移的关系。结果:血清PSA≤10μg/L者骨转移的发生率极低,发生率为0。PSA≥20μg/L者有骨转移的可能,骨转移的发生率为50%。PSA≥40μg/L者骨转移的可能性极大,骨转移的发生率为68%。结论:对于新诊断而未治疗的前列腺癌的患者,PSA<10μg/L者无骨痛或病理性骨折时不必行全身核素骨显像检查。PSA≥20μg/L者应常规行全身核素骨显像检查,以早期确诊前列腺癌骨转移。

Objective：To probe into the correlation between serum PSA and bone metastasis in prostatic cancer. Methods：Serum PSA in 121 cases of prostatic cancer was retrospectively reviewed as to its correlation with bone metastasis, the radionuclide bone scan being taken as the golden standard for bone metastasis. Results：The results revealed that when PSA was less than 10 μg/L, the possibility of existing bone metastasis was extremely low. When it was above 20 μg/L,bone metastasis should be considered. When it was above 40 μg/L bone metastasis is in high suspect. Conclusions：We concluded that radionuclide bone scans are unnecessary for the staging of previously untreated prostate cancer patients who have no skeletal symptoms and a serum PSA value of less then 10 μg/L. When it was above 20 μg/L,radionuclide bone scans was necessary.