摘要
目的:探讨表皮生长因子受体(Epidermal growthfactor receptor,EGFR)和环氧化酶-2(Cyclooxygenase-2,COX-2)在前列腺癌(Prostate cancer,PCa)中的共同表达和临床意义。方法:采用免疫组织化学法(SP)测定48例PCa中EGFR和COX-2阳性表达情况,按免疫组织化学结果分为EGFR(-)COX-2(-)、EGFR(-)COX-2(+)、EGFR(+)COX-2(-)和EGFR(+)COX-2(+)四组,分析它们表达与临床病理和预后的关系。结果:EGFR、COX-2阳性在PCa中为34例(70.8%)、21例(45.8%),两者的表达在PCa中无相关性(r=0.04,P=0.80),EGFR和COX-2共同表达有16例(33.3%),和Gleason评分、PSA水平有关(P<0.05),5年复发率83.1%,显著高于EGFR(+)COX-2(-)(27.8%)、EGFR(-)COX-2(+)(16.7%)和EGFR(-)COX-2(-)(12.5%)(P<0.05);13例转移PCa中有10例为EGFR(+)COX-2(+)(62.5%),显著高于其他三组(P<0.05)。结论:EGFR和COX-2在PCa中表达无相关性,但其共同表达可以作为判断PCa预后的重要标志。
Objective:To explore the co-expression of epidermal growth factor receptor(EGFR)and cyclooxygenase-2(COX-2) as well as their clinic significance in prostate cancer. Methods:Protein expression of EGFR and COX-2 in formalin-fixed and paraffin-embedded blocks of 48 PCa tissues was analyzed by immunohistochemical method and then were divided into four groups : EGFR ( - ) COX-2 ( - ) ; EGFR ( - ) COX-2 ( + ) ; EGFR ( ) COX-2 ( - ) ; EGFR ( + ) COX-2 ( + ). Results: Positive rate of EGFR and COX-2 expression in PCa was 70.8% and 45.8% ,There was no relationship between EGFR and COX-2 expression(r=0.04 ,P=0.80). Co-exprssion of EGFR and COX-2 was shown in 16 PCa tissues (33.3%). There was statistically positive correlation with high Gleason score and PSA. Of the patients in four groups ,patients positive for both EGFR and COX-2 proteins was found to higher in 5-year recurrence rate(83.1%) compared, with 27.8% for EGFR(+)COX-2(-),16.7% for EGFR (-)COX-2(+) ,12. 5% for EGFR(-)COX-2(-). There was 10 co-exprssion of EGFR and COX-2 in 13 metastasis PCa while only 3 in other three groups(P〈0.05). Conclusions: There was no relationship between EGFR and COX-2 expression in PCa, but their co-expression maybe serve as a new important of prognostic marker.
出处
《临床泌尿外科杂志》
2008年第4期283-285,288,共4页
Journal of Clinical Urology