Caveolin-1和E-cadherin在肾细胞癌中的表达及其意义

Expression of Caveolin-1 and E-cadherin in renal cell carcinoma

目的:探讨Caveolin-1、E-cadherin在肾细胞癌中的表达及其临床意义。方法:采用免疫组织化学EnVision法检测41例肾细胞癌切除标本中Caveolin-1和E-cadherin的表达,并分析表达情况与肿瘤的生物学行为的关系。结果:Caveolin-1在肾细胞癌中的表达阳性率为41.5%,与肿瘤分期、Fuhrman分级及患者年龄呈正相关(P<0.05);E-cadherin表达阳性率为24.4%,低于癌旁肾组织(50%),E-cadherin表达与肿瘤细胞核分级相关(P<0.05),与其他临床病理参数之间无相关性。Caveolin-1和E-cadherin两者之间表达无相关性。结论:Caveolin-1过表达及E-cadherin的异常表达,可能在肾细胞癌的生长、分化中发挥重要作用。

Objective：To evaluate expression of Caveolin-1 and E-cadherin in renal cell carcinoma and to investigate their associations with clinicopathological parameters. Methods： Expression of Caveolin-1 and E-cadherin were evaluated by immunohistochemistry in 41paraffin embedded renal cell carcinoma specimens. Associations between their expressions and pathological stage, tumor grade, size of tumor were analyzed. Results： Of 41 tumors 17 （41.5 % ） were considered Caveolin-1 positive. Significant associations between Caveolin-1 expression and pathological stage, tumor grade,and age of patient were also found（P〈0.05）. Positive rate of E-cadherin expression in 41 tumors is 24.4%, which was lower than in nomal tissues. Associations between E-cadherin expression and tumor grade was found（P〈0.05）. There were no significant associations between E-cadherin expression and other clinicopathological parameters, Conclusions： Caveolin-1 over expression and abnomal expression of E-cadherin might have an important role in growth and differentiation of renal cell carcinoma.