国人前列腺炎、前列腺增生与前列腺癌的关系

Relationship between prostatitis,benign prostatic hyperplasia and prostate cancer in chinese population

目的：探讨国人前列腺炎、前列腺增生与前列腺癌的关系，为预防决策提供依据。方法：分别以“前列腺炎”、“前列腺增生”、“前列腺癌”等为检索词，收集1979年1月～2007年6月国内公开发表的关于国人前列腺疾患与前列腺癌的研究文献，并用RevMan4．2软件对这些文献进行Meta分析；根据固定效应模型和随机效应模型计算结果的一致程度进行敏感性分析。结果：纳入本次Meta分析的文献共有4篇，累计病例487例，对照1850例。前列腺炎、前列腺增生与前列腺癌发生的并发相对危险度（OR）值为4．69及95％可信区间（95％CI）为0．60～6．10（P〈0．05）。结论：前列腺炎，前列腺增生是国人前列腺癌发病的危险因素。

Objective： To provide evidence for decision-making on prostate cancer prevention through investigating the relationship between prostatitis, benign prostatic hyperplasia and prostate cancer in Chinese Population. Methods： Using the search terms＂Prostatitis＂ ＂ Benign prostatic hyperplasia＂ and ＂Prostate cancer＂, the literature from January 1979 to June 2007 on the relationship between Prostatitis,Benign prostatic hyperplasia and Prostate cancer was searched from, and was studied by Meta-analysis. RevMan 4.2 software was applied process date. At the same time, ORs（odd ratio） of randomized effect model and fixed effect model were calculated to evaluate the sensitivity. Results： Totally, 4 epidemiological studies on Prostatitis, Benign prostatic hyperp lasia and Prostate cancer were analyzed synthetically by Meta-analysis. The cumulative cases and the controls were 487 and 1850 respectively. The pooled odds ratio （OR） values and 95 % CIs were as follows： Prostatitis;Benign prostatic hyperp lasia 4.69 （0. 60- 6.10） respectively （ P〈0. 05）. Conclusions： Prostatitis; Benign prostatic hyperplasia is the influncing factors of Prostate cancer in Chinese population.