地黄双花颗粒抗炎止痒镇痛作用的药效学

Effect of Dihuangshuanghua granules on anti-inflammation,analgesia and relieving itching in animals

目的:研究地黄双花颗粒(DG)抗炎、止痒、镇痛作用。方法:用小鼠耳肿法及大鼠足肿胀法观察其抗炎作用;小鼠扭体法;组胺所致豚鼠瘙痒法。结果:DG能减少醋酸致小鼠扭体反应次数;明显减轻二甲苯致小鼠耳部的炎症肿胀;有效抑制角叉菜胶致大鼠足跖的急性炎症;提高豚鼠对磷酸组织胺的致痒阈。结论:DG对实验动物模型具有明显的抗炎、止痒和镇痛作用。

OBJECTIVE To study anti-inflammatory,analgesic and antipruritic effects of Dihuangshuanghua granules（DG）. METHODS Anti-inflammatory effects were observed by xylene-induced ear acute oedema in mice and carrageenan-induced hind paw oedema in rats,analgesic action by writhes in mice,antipruritic action by itch threshold of guinea pigs caused by phosphoric acid histamine. RESULTS DG could decrease the twisng reaction times caused by acetic acid. DG could efficiently prevented ears swelling ofmice and the acute inflammation induced by carrageenan. The allergic pruritic to leranee in guinea pigs was in creased. CONCLUSION DG has obvious anti-inflammatory, analgesic and antipruritic effects.