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特发性肺纤维化的治疗进展 被引量：3

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摘要 特发性肺纤维化（idiopathic pulmonary fibrosis，IPF）是一种以普通型间质性肺炎（usual interstitial pneumonitis）为特征性病理改变的慢性、弥漫性肺间质疾病。其病因不明，发病机制不清．缺乏有效治疗手段，IPF确诊后平均存活期为2～4年．5年生存率为30％～50％。其临床主要表现为进行性呼吸困难和刺激性干咳。IPF的研究进展缓慢，预后很差，诊断后的中位生存时间为4年，目前还没有有效的治疗手段。本文就其治疗研究的新进展做一综述。
作者 刘小燕 李时悦
机构地区 广州医学院第一附属医院广州呼吸疾病研究所
出处 《实用医学杂志》 CAS 2008年第9期1467-1469,共3页 The Journal of Practical Medicine
关键词 特发性肺纤维化 有效治疗 PULMONARY 普通型间质性肺炎 弥漫性肺间质疾病 进行性呼吸困难 5年生存率 刺激性干咳
分类号 R563.9 [医药卫生—呼吸系统]
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参考文献23

  • 1高晓方,崔社怀.特发性肺纤维化的抗纤维化治疗研究进展[J].中华结核和呼吸杂志,2004,27(6):366-368. 被引量：27
  • 2Sime P J, O' Reilly K M. Fibrosis of the lung and other tissues : new concepts in pathogenesis and treatment [J]. Clin Immunol, 2001,99(3) :308-319.
  • 3American Thoracic Society. Idiopathic fibrosis: diagnosis and treatment. International Consensus Statement. American Thoracic Society and the European Respiratory Society [J ]. Am J Respir Crit Care Med, 2000, 161(2 Pt 1):646-664.
  • 4Spyros A P, George K, Marilena K, et al. Relationship of BAL and lung tissue CD4 and CD8 T lymphocytes, and their ratio hi idiopathic pulmonary fibrosis [J]. Chest, 2005,128 (4) :2971-2976.
  • 5Cortijo J, Cerda-Nicolas M, Serrano A, et al. Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats [J]. Eur Respir J, 2001,17(6) : 1228-1235.
  • 6Demedis M B, Convasce G C, Dekhuijzen R, et al. IFIGENIA. effects of N-acctylcuseine (NAC) on primary end points VC and dico [J]. Eur Respire J, 2004,24(4):668S.
  • 7Vuokko L K, Cheryl L F, Roderick J T, et al. Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy [J]. Am J Res Crit Care Med, 2005,172(4):417-422.
  • 8Liu H, Drew P, Cheng Y, et al. Pirfenidone inhibits inflammatory responses and ameliorates allograft injury in a rat lung transpant model [J]. J Thorac Cardiovasc Surg, 2005,130 ( 3 ) : 852-858.
  • 9Azuma A, Nukiwa T, Tsuboi E, et al. Double-blind, placebocontrolled trial of pirfenidone in patients with idiopathic pulmonary fibrosis [J]. Am J Respir Crit Care Med, 2005,171 (9) : 1040-1047.
  • 10Douglas W W, Ryu J H, Schroeder D R, Idiopathic pulmonary fibrosis: impact of oxygen and colchicines, prednisone, or no therapy on survival [J]. Am J Respir Crit Care Med, 2000, 161 (4 Pt 1): 1172-1178.

二级参考文献22

  • 1Selman M, King TE Jr, Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med, 2001, 134: 136-151.
  • 2Iyer SN, Hyde DM, Giri SN. Anti-inflammatory effect of pirfenidone in the bleomycin-hamster model of lung inflammation. Inflammation, 2000, 24: 477-491.
  • 3Raghu G, Johnson WC, Lockhart D, et al. Treatment of idiopathic pulmonary fibrosis with a new antifibrotic agent, pirfenidone: results of a prospective, open-label Phase Ⅱ study. Am J Respir Crit Care Med, 1999, 159: 1061-1069.
  • 4King TE Jr . Treatment advances and failures in pulmonary fibrosis. European Respiratory Society (ERS) Annual Congress, 2002 Sep 18. Sweden:Stockholm, Available from: URL: http://www.ersnet.org/2/4/2-4.asp.
  • 5Erickelberg O, Pansky A, Koehler E, et al. Molecular mechanisms of TGF-(beta) antagonism by interferon (gamma) and cyclosporine A in lung fibroblasts. FASEB J, 2001, 15: 797-806.
  • 6King TE Jr. Interferon gamma-1b for the treatment of idiopathic pulmonary fibrosis. N Engl J Med, 2000, 342: 974-975.
  • 7Noble P. Pathology and current treatment options of idiopathic pulmonary fibrosis. European Respiratory Society (ERS) Annual Congress, 2002 Sep 18. Sweden:Stockholm, Available from: URL: http://www.ersnet.org/2/4/2-4.asp.
  • 8Sciavolino PJ, Lee TH, Vilcek J. Interferon-beta induces metalloproteinase mRNA expression in human fibroblasts. Role of activator protein-1. J Biol Chem, 1994, 269: 21627-21634.
  • 9Wang R, Ibarra S, Verlinshi L, et al. Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor. Am J Physiol Lung Cell Mol Physiol, 2000, 279: L143-151.
  • 10Mason RJ, Schwarz MI, Hunninghake GW, et al. NHLBI workshop summary. Pharmacological therapy for idiopathic pulmonary fibrosis. Past, present, and future. Am J Respir Crit Care Med, 1999, 160: 1771-1777.

共引文献32

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实用医学杂志
2008年 第9期

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