芳并呋喃类化合物的—锅化合成法

One - pot Synthetic Method of The Benzofuran Compounds

本文报道用KF/Al_2O_3作为碱催化剂,由水杨醛或2-羟基-1-萘醛分别和α-溴代乙酸酯、α-溴代苯乙酮、苄基氯、4,4’-二氯甲基联苯和1,5-二氯甲基萘等进行一锅化缩合反应,以38～89％的产率合成了14种芳并呋喃化合物。

In the precence of the base catalyst KF/Al2O3, the one - pot reaction of 2 -hydroxybenzaldehyde or 2 - hydroxynaphthaldehyde with ethyl α - bromoacetate, ( α -bromoacetophenone , 1,4 - dichloromethylbenzene , 4,4' - dichloromethylbiphenyl and 1,5 -dichloromethylnaphthalene gave the benzofuran compounds in 38-89% yield.