噬菌体展示技术在纳米材料合成中的应用

Application of phage display techniques in synthesis of nanomaterials

建立在化学、生物学和材料学等交叉学科基础上的噬菌体展示技术,为合成、组装新颖纳米材料提供了一条新的途径。噬菌体作为一种信息载体,能模拟自然进化过程产生特异性多肽,从而在分子水平上识别靶材料并进行自组装。噬菌体的单分散性和长杆状外形,造就了特定的识别部位,使各种纳米材料有序地组装成规则的层次结构。通过噬菌体展示技术筛选出来的特异性识别肽,可以指导多肽介导的矿化过程,从而合成具有应用价值的一系列无机和有机纳米材料,进一步制成的纳米装置将应用于电子、光学、生物技术和医学领域。

Phage display techniques （PDT） provide unprecedented approaches to synthesize and assemble novel nanomaterials by combining chemistry, biology and materials science principles. Through simulating the evolution process in nature, some phage is used as an information-carrier to identify specific peptide that can recognize target materials at the molecular level. The monodispersity and long rod shape of the phage enable the organization of various nanomaterials into regularly ordered hierarchies. The specific recognition peptides of the phage screened by PDT can direct peptide-mediated mineralization processes to create many useful inorganic and organic nanomaterials, which could be useful for electronic, optical, biotechnological and medical application in the future.