江苏地区乳腺癌危险因素的病例对照研究

The risk factors of breast cancer in Chinese women:a case-control analysis

目的:调查江苏地区女性乳腺癌危险因素,为确定高危人群、提出预防措施提供依据。方法:采用以医院为基础的病例对照研究,对江苏地区经病理证实的515例乳腺癌患者,按照年龄和地区匹配,选取对照515例进行统一的问卷调查,用SPSS13.0软件进行单因素和多因素logistic分析。结果:在单因素分析中,达到显著性水平的危险因素为首次活产年龄大、有流产史、初潮年龄小、有肿瘤家族史等,达到显著性水平的保护因素为母乳喂养及口服避孕药。非条件logistic多元回归分析显示,有统计学意义的乳腺癌危险因素是肿瘤家族史、有流产史,重要保护性因素是母乳喂养。结论:江苏地区女性乳腺癌发病不仅与月经生育史有关,还与肿瘤家族史有一定联系。

Objective：To explore the risk factors of breast cancer among women in Jiangsu Province. Methods：A case-control study and univariate and multivariate logistic regression were employed to evaluate the association of menstrual and reproductive factors with breast cancer in 515 breast cancer cases and 515 controls. Univariate and multivariate logistic regression analysis were carried out with SPSS13.0 software. Results： In the univariate logistic analysis, subjects with elder age at first live birth, menarche ≤ 15 years, having the history of abortion, and familial history of cancer are the statistically significant risk factors of breast cancer, whereas breast feeding, oral contraceptives are the protective factors. Multivariate logistic analysis also revealed that familial history of cancer and the history of abortion are the risk factors while the breast feeding is a protective factor. Concluslon：Menstrual and reproductive factors and familial history of cancer among women in Jiangsu province are associated with the breast cancer.