逍遥散加味治疗抗痨药物性肝损害58例疗效观察

Therapeutic Effect of Modified Xiaoyao Powder for the Treatment of Hepatic Injury Induced by Anti-tuberculosis Drugs

目的:观察逍遥散加味治疗抗痨药物性肝损害的疗效。方法:将120例患者随机分为2组,对照组62例以肝利欣、联苯双脂滴丸、护肝片、肌苷片治疗。治疗组58例在对照组治疗基础上加用逍遥散加味治疗。结果:治疗组治愈率为70.68%,总有效率为100%。对照组治愈率为48.39%,总有效率为98.39%。2组治愈率比较,差异有显著性意义(P<0.05);2组总有效率比较,差异无显著性意义(P>0.05)。肝功能恢复正常平均时间:治疗组为28.5天,对照组为44.6天,2组比较,差异有显著性意义(P<0.05)。抗痨化疗方案被迫改变例数:治疗组28例,对照组62例,2组比较,差异有非常显著性意义(P<0.01)。结论:逍遥散加味治疗药物性肝损害能显著提高结核病患者联合化疗方案的规范服药率,有减毒增效作用。

Objextive:To observe the therapeutic effect of Modified Xiaoyao Powder (MXP)for the treatment of hepatic injury induced by anti-tuberculosis drugs. Meth- ods:One hundred and twenty patients were randomized into two groups:the control group(n=62)received the treatment with Ganlixin,Biphenyl Dimethyl-dicarboxylate Dropping Pills,Hugan Tablets and Inosine Tablets,and the treatment group(n=58) received MXP on the basis of the routine treatment of the control group. Results:The cure rate was 70.68% and the total effective rate was 100% in the treatment. In the control group,the cure rate was 48.39% and the total effective rale was 98.39%. The difference of the cure rate was significant while that of the total effective rate was insignifi- cant(P>0. 05). The mean time for hepatic function recovering to normal was 28.5 days in the treatment group and 44.6 days in the control group(P<0.05). The number of patients whose anti-tuberculosis regimen was changed was 28 in the treatment group and 62 in the control group(P<0.01). Conclusion:MXP has synergism and attenuation actions for patients with hepatic injury induced by anti-tuberculosis drugs.