慢性病毒性肝炎患者血清sICAM-1与肝组织病理变化的相关性研究

The association of serum soluble intercellular adhesion molecule-1 level with hepatic histopathology in patients with chronic hepatitis

目的评价sICAM-1在慢性肝病诊治中的临床意义。方法对130例慢性肝炎患者血清sICAM-1、纤维化指标和肝活检病理改变等进行相关性研究。结果ICAM-1在慢性肝炎肝组织的表达与炎症活动度、肝纤维化程度均呈显著正相关。血清sICAM-1水平与肝组织ICAM-1表达呈显著正相关(r=0.64,P<0.01),并与慢性肝炎的临床及病理分度呈一致性改变。血清sICAM-1水平与HA、PCⅢ、CⅣ、LN亦有良好的相关性(P<0.01)。结论慢性肝炎患者肝组织及血清ICAM-1水平可一定程度反映肝脏炎症和纤维化程度。血清sICAM-1水平的监测可作为临床判断慢性肝炎病情严重程度和预后的重要免疫学指标之一。

Objective To study the correlation of serum soluble intercellular adhesion molecule-1 （sICAM-1） level to liver pathology in patients with chronic hepatitis. Methods Liver biopsies were performed on 130 patients with chronic hepatitis and the serum fibrotic markers were detected in the corresponding period. The level of serum sICAM-1 was detected by ELISA and expression of ICAM-1 in liver was observed by immunohistochemistry. Results The level of serum sICAM-1 was positively related to the ICAM-1 expression in the liver（P〈0.01）,and also to the severity of clinical manifestation and pathological change in liver （P〈0.01）. Furthermore,serum sICAM-1 was positively related with HA,PCⅢ,C ⅣandLN （P〈0.01）. Conclusion The serum sICAM-1 might be a new marker for liver inflammation and fibrosis in patients with chronic hepatitis.