子宫内膜癌ER、PR的表达及其临床意义

Expression and clinical significance of ER and PR in endometrium carcinoma

目的检测子宫内膜癌组织中雌激素受体(ER)、孕激素受体(PR)阳性表达率并探讨其临床意义。方法应用免疫组化技术对47例子宫内膜癌组织进行ER、PR检测,结合临床及病理指标进行分析。结果ER、PR在47例子宫内膜癌的阳性表达率分别为57·4%和61·7%,ER、PR的双阳性、双阴性分别为48·9%和29·8%。ER、PR在子宫内膜癌的阳性表达率与组织学分级密切相关,随组织学分级的增高,其阳性表达率逐渐降低,有统计学意义(P<0·05)。ER、PR的表达与肌层浸润、子宫外病灶有关,差异有统计学意义(P<0·05)。结论ER、PR均反应了子宫内膜癌的生物学行为,是一个可以综合反映病程、病情和病变性质的客观指标,其测定对估计患者预后,指导临床选择激素治疗具有重要意义。

Objective To the expression rate of estrogen receptor（ER）and progestin receptor（PR）in endometrium carcinoma tissue and to discuss its clinical significance.Methods To detect ER and PR of 47 cases endometrium carcinoma tissue ,moreover, clinic and pathology analyse to them by immunohistochemistry technology Results In 47 cases endometrium carcinoma,the positive expression rate of ER and PR were 57.4%and 61.7%respectively.Both ER and PR positive and negative expression rate were 48.9% and 29.8%respectively.ER and PR positive expression rate had relation to histological differentiation and gradually reduced with heightening of histological differentiation,which was statiscal significance（P〈0.05）.Expression of ER and PR were correlated with uterus muscle layer＇s soakage and uterus outer focus,was statistical significance（P〈0.05）.Conclusion ER and PR all reflected biological behavior about endometrium carcinoma and was comprehensive guideline that may respond a disease＇s course and state and pathological change＇s character.It＇s menstruation were important in estimating the prognosis and directing clinic in choosing endocrine therapy.