摘要
目的观察经鼻持续气道正压通气(nCPAP)治疗对老年高血压病合并中重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血小板活性及P选择素的影响。方法入选老年高血压病合并中重度OSAHS患者45例,按患者意愿及对nCPAP耐受情况,分为nCPAP治疗组及对照组,检测治疗前及治疗30d后血小板活性和P-选择素水平。结果nCPAP治疗30d后血清血小板活性和P-选择素较治疗前显著下降(P<0·001),对照组无明显变化(P>0·05)。结论nCPAP治疗可降低老年高血压病合并中重度OSAHS患者血小板活性及P-选择素水平。
Objective To investigate the effect of nasal continuous positive airway pressure（nCPAP）treatment on platelets activity and P-selectin in elderly hypertension patients with moderate or severe obstructive sleep apnea-hypopnea syndrome（OSAHS）.Methods 45 elderly hypertension patients with moderate or severe OSAHS were divided into two groups：nCPAP treatment group and control group.The platelet aggression（PAG）and P-selectin were tested on the time of pretreatment,and 30 days later of treatment.Results 30 days of nCPAP treatment lowered the level of PAG and P-selectin（P〈0.001 vs pretreatment）.Conclusion nCPAP treatment can decrease the level of PAG and P-selectin in elderly hypertension patients with moderate or severe OSAHS.
出处
《中国实用医药》
2008年第15期70-71,共2页
China Practical Medicine
