刺五加香薷合剂药理作用的观察

Pharmacological effects of Mixture of Eleutherococcus (ELE)and Elscholtzia (ELS)

在实验期分别为10～110天的动物(小白鼠和大白鼠)和人体实验中,观察到合剂具有如下作用:增强小鼠对低温和酒精的耐受力,改善阴虚和阳虚小鼠的免疫功能,减少老龄雄性大鼠大脑皮质中去甲肾上腺素的含量,抑制老龄大鼠肝和大脑皮质的脂质过氧化反应,调节老龄雌性大鼠和高脂血症者的血脂,特别是增加血清HDL-C 的含量。合剂的抗脂质过氧化作用是刺五加和香薷配伍后出现的作用。

Pharmacological effects of ELE,ELS and their mixture(per os)were observed in a series of experiments (10 to 110 days) in mice,rats and human.The effects of the mixture included enhancement ofthe endurance of mice to cold and alcohol,improvement of the immunefunction of the Yin-deficiency and Yang-deficiency mice,inhibitonof the lipid peroxidation of liver and cerebral cortex of old rats,de-crease of the NA content of cerebral cortex of old male rats,and re-gulation of the level of serum lipids of old female rats and hyper-lipemic human subjects,especially increase of the serum content ofHDL-C.The inhibiting effect of the mixture on lipid peroxidationwas observed only after ELE and ELS were mixed,while the regulat-ing effect of the mixture on serum lipids was mainly the effect ofELE.