异维A酸隔日疗法和每日疗法治疗痤疮疗效比较

Comparison of therapeutic efficacy of intermittent and daily isotretinoin in the treatment of acne

目的:观察异维A酸(泰尔丝)隔日疗法和每日疗法治疗痤疮的疗效,以及在保证疗效的前提下唾液腺分泌减少的发生率。方法:将受试者分为两组,即异维A酸隔日疗法B组(试验组)和每日疗法组(对照组)。试验组中体重≥50kg者,隔日口服异维A酸10mg,每日3次;体重<50kg者,隔日口服异维A酸10mg,每日2次。对照组中体重≥50kg者,每日口服异维A酸3次,每次10mg;体重<50kg者,每日口服异维A酸2次,每次10mg,两组患者疗程均为6周。结果:经过6周的治疗,试验组患者有效率为77.17%,对照组患者有效率为85.00%。第2、4、6周末时试验组和对照组患者唾液腺分泌减少的发生率分别为26%、31.25%、32.18%和28.87%、34.12%、48.68%。结论:异维A酸隔日疗法治疗痤疮的疗效与每日疗法相当,唾液腺分泌减少的发生率更低。

Objective： To evaluate the efficacy of intermittent and daily isotreinoin in the treatment of acne, and to observe the incidence decrease of salivary secretion with expected therapeutic effect. Methods： Patients were randomly divided into two groups： intermittent isotretinoin therapy group （treatment group） and daily isotretinoin therapy group （control group）. In the treatment group, the drug was given every other day. The patients whose weight≥50 kg were given the drug 10 mg, 3 times a day, and the patients whose weight〈50 kg were given the drug 10 mg, 2 times a day. In the control group, the drug was given every day. The patients whose weight≥50 kg were given the drug 10 mg, 3 times a day, and the patients whose weight〈50 kg were given the drug 10 mg, 2 times a day. The course of treatment was 6 weeks for both groups. Results： After 6 weeks＇ treatment, the effective rates of the treatment group and control group were 77.17% and 85.00% respectively. At the end of the 2nd, 4th, 6th weeks, the incidences of salivary secretion decreasing in the treatment group were 26%, 31.25% and 32.18% respectively, while those for the control group were 28.87%, 34.12% and 48.68% respectively. Conclusions： The intermittent isotretinoin therapy has the same efficacy and a lower incidence of salivary secretion decrease compared with the daily isotretinoin therapy in the treatment of aene.