摘要
目的:观察异维A酸(泰尔丝)隔日疗法和每日疗法治疗痤疮的疗效,以及在保证疗效的前提下唾液腺分泌减少的发生率。方法:将受试者分为两组,即异维A酸隔日疗法B组(试验组)和每日疗法组(对照组)。试验组中体重≥50kg者,隔日口服异维A酸10mg,每日3次;体重<50kg者,隔日口服异维A酸10mg,每日2次。对照组中体重≥50kg者,每日口服异维A酸3次,每次10mg;体重<50kg者,每日口服异维A酸2次,每次10mg,两组患者疗程均为6周。结果:经过6周的治疗,试验组患者有效率为77.17%,对照组患者有效率为85.00%。第2、4、6周末时试验组和对照组患者唾液腺分泌减少的发生率分别为26%、31.25%、32.18%和28.87%、34.12%、48.68%。结论:异维A酸隔日疗法治疗痤疮的疗效与每日疗法相当,唾液腺分泌减少的发生率更低。
Objective: To evaluate the efficacy of intermittent and daily isotreinoin in the treatment of acne, and to observe the incidence decrease of salivary secretion with expected therapeutic effect. Methods: Patients were randomly divided into two groups: intermittent isotretinoin therapy group (treatment group) and daily isotretinoin therapy group (control group). In the treatment group, the drug was given every other day. The patients whose weight≥50 kg were given the drug 10 mg, 3 times a day, and the patients whose weight〈50 kg were given the drug 10 mg, 2 times a day. In the control group, the drug was given every day. The patients whose weight≥50 kg were given the drug 10 mg, 3 times a day, and the patients whose weight〈50 kg were given the drug 10 mg, 2 times a day. The course of treatment was 6 weeks for both groups. Results: After 6 weeks' treatment, the effective rates of the treatment group and control group were 77.17% and 85.00% respectively. At the end of the 2nd, 4th, 6th weeks, the incidences of salivary secretion decreasing in the treatment group were 26%, 31.25% and 32.18% respectively, while those for the control group were 28.87%, 34.12% and 48.68% respectively. Conclusions: The intermittent isotretinoin therapy has the same efficacy and a lower incidence of salivary secretion decrease compared with the daily isotretinoin therapy in the treatment of aene.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2008年第6期394-395,共2页
Journal of Clinical Dermatology