绞股蓝及运动训练对中年大鼠主动脉壁脂质氧化水平和血脂含量的影响

Effect of Gynostemma Pentaphyllum and Exercise Training on the Levels of Lipid Peroxide in the Aortic Wall and Serum Lipids in the Middle- aged Rats

测定了中年大鼠主动脉壁脂质过氧化水平和抗氧化酶活性以及血脂的变化。２４只１２月龄的雄性Ｗｉｓｔａｒ大鼠随机分为４组：对照组、服药组、训练组和服药＋训练组。后二组在跑台上训练８周（５天／周，每天训练２０～３０分钟，速度１５～２０米／分，坡度５％）。结果如下：（１）服药、训练组体重明显下降。（２）与对照组比，服药组和训练组ＭＤＡ含量明显下降，ＳＯＤ和ＧＳＨ－Ｐｘ活性明显升高（Ｐ＜０．０５）；服药＋训练组与对照组比较，ＭＤＡ含量以及ＳＯＤ和ＧＳＨ－Ｐｘ活性有极显著性差异（Ｐ＜０．０１）；服药＋训练组ＧＳＨ－Ｐｘ活性高于服药组和训练组，差异有显著性。（３）与对照组比较，后三组血清ＨＤＬ－Ｃ以及ＨＤＬ－Ｃ／ＴＣ明显增加，服药组与服药＋训练组ＴＧ和ＴＣ含量下降明显，而训练组ＴＧ和ＴＣ变化不显著。提示绞股蓝及运动训练在抗脂质过氧化和调节脂代谢方面有显著作用。文章探讨了绞股蓝和运动训练抗动脉粥样硬化的可能机制。

Twenty-four male Wistarr rats (12-mo-old)were randomly divided into four grouups: control,drug,training and drug+ training.The training and drug+traing rats performed a8- week treadmill exercise training program (5days/week, 20 ～30min/day, 15～ 20m/min, 5%). Malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the aortic wall and serum lipids were measured.The results were as follows:1.The weights of the rats were significantly lower in drug+training group.2.In both drug and training groups,MDA content decreased(P<0.05)while the activities of SOD and GSH-Px increased as compared with control group. MDA content was lower and the activities of SOD and GSH-Px were higher(P<0. 01)in drug+ training group as compared with control group.GSH-Px activity in drug+training group was higher(P<0.05)than that in drug and trained groups,respectively.3.HDL-Cand HDL-C/TC levels increased in drug、training and drug+ training groups.TG and TC decreasedindrug and drug+training groups,while unchanged in trained group.These results suggested that Gynostemma Pentaphyllum and exercise training have significant effects on anti - lipid peroxide andon serum lipids metabolism and may be beneficial to antiatherosclerosis.