清肠灌肠方治疗溃疡性结肠炎临床疗效及对VEGF的影响

Effect of Qingchang Guanchang Fang on Treatment of Ulcerative Colitis and VEGF Expression

目的:观察"清肠灌肠方"对溃疡性结肠炎(UC)患者的临床疗效及对血管内皮生长因子(VEGF)的影响。方法:将UC患者60例随机分为"清肠灌肠方"治疗(中药组)和柳氮磺胺吡啶治疗(SASP组),各30例。治疗4周后,观察临床症状、结肠镜下黏膜改变以及治疗前后VEGF表达的变化。结果:中药组症状改善和结肠镜下黏膜炎症修复情况均优于SASP组(P<0.05),提高VEGF表达作用优于SASP组(P<0.05)。结论:"清肠灌肠方"治疗UC疗效显著,该方通过提高VEGF表达提高溃疡愈合质量,可能是其促进溃疡愈合的机制之一。

Objective ： To observe the effect of Qingchang Guanchang Fang on treatment of ulcerative colitis （ UC and VEGF expression. Methods： 60 cases with UC were randomly divided into TCM group treated by Qingchang Guanchang Fang （30 cases） and SASP group treated by salicylazosulfapyridine （30 cases）. After therapy for 4 weeks, the clinical curative effect, variation of mucous membrane by the enteroscopy, and VEGF expression before and after the therapy were observed. Results：The symptom improvement and the restoration of mucous membrane＇s inflammation in the TCM group were obviously better than those in the SASP group （ P 〈 0.05）. VEGF expression in the TCM group was also increased compared with that in the SASP group （P 〈 0.05）. Conclusion： Qingchang Guanchang Fang has significant curative effect on treatment of UC. Improvement of VEGF expression and ulcer concrescence quality maybe the mechanicsm of Qingchang Guanchang Fang in acceleration of ulcer concrescence.