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p53基因突变的检测方法及临床应用 被引量：3

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作者 周卫平 王惠民 贾春平
机构地区 通州市人民医院检验科 南通大学附属医院检验科 中国科学院上海微系统与信息技术研究所
出处 《临床检验杂志》 CAS CSCD 北大核心 2008年第3期224-226,共3页 Chinese Journal of Clinical Laboratory Science
基金 国家863课题(2006AA03Z334) 南通市社会发展计划(指导性)项目(S7926)
关键词 P53基因 基因突变 肿瘤
分类号 Q754 [生物学—分子生物学]
  • 相关文献

参考文献19

  • 1Eliyahu D, Dmichalovitz D, Eliyahu S,et al. Wild-type p53 can inhibit oncogene-mediated focus formation [ J ]. Proc Natl Acad Sci USA, 1989,86(22 ) :8763-8767.
  • 2Donehower L A,Harvey M, Slagle B ,et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours [ J ]. Nature,1992,356(6366) :215-221.
  • 3Michael B, Onyinye O, David S, et al. Participation of p53 protein in the cellular response to DNA damage [ J]. Cancer Res, 1991,51 (23) :6304-6311.
  • 4Greenblatt M S, Bennett W P,Hollstein M,et al. Mutations in the p53 tumor suppressor gene:Clues to cancer etiology and molecular pathogenesis [ J ]. Cancer Res, 1994,54 ( 18 ) :4855-4878.
  • 5Kim J H,Takahashi T, Chiba I, et al. Occurrence of p53 gene abnormalities in gastric carcinoma tumors and ceils lines[ J]. Natl Cancer Inst, 1991,83 ( 7 ) : 938-943.
  • 6Cotton R G H, Rodrigues N R, Campbell RD. Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations [ J ].PNAS, 1988,85:4397-4401.
  • 7Tchernitchko D, Lamoril J, Puy H, et al. Evaluation of mutation screening by heteroduplex analysis in acute intermittent porphyria: comparison with denaturing gradient gel electrophoresis [ J ]. Clin Chim Acta, 1999,279 ( 1 ) : 133-143.
  • 8林炳承.毛细管分析导论.北京:科学出版社,1996:132.
  • 9方能虎,蔺丽,任吉存,吴旦.变性高效液相色谱——一种新的基因突变检测方法[J].化学进展,2005,17(2):343-349. 被引量：8
  • 10Eva G, Marion K, Norbert A. Mutation analysis of p53 in ovarian tumors by DHPLC[ J]. J Brochem Biophy Methods,2001,47 ( 1-2 ) : 73 -81.

二级参考文献124

  • 1[1]Parkin M,Bray F,Ferlay J,et al.Global Cancer Statistics 2002[J].CA Cancer J Clin,2005,55:1074-1082.
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  • 3[3]Flaman J M,Frebourg T,Moreau V,et al.A simple p53 functional assay for screening cell lines,blood,and tumors[J].PNAS,1995,92(9):3963-3967.
  • 4[4]Cho Y,Gorina S,Jeffrey P D,et al.Crystal structure of a p53 tumor suppressor-DNA complex[J].Science,1994,265(5170):346-355.
  • 5[5]Gietz D,St Jean A,Woods R A,et al.Improved method for high efficiency transformation of intact yeast cells[J].Nucleic Acids Res,1992,20(6):1425.
  • 6[6]Levine A J.p53,the cellular gatekeeper for growth and division[J].Cell,1997,88(3):323-331.
  • 7[7]Vogelstein B,Lane D,Levine A J.Surfing the p53 network[J].Nature,2000,408(6810):307-310.
  • 8[8]Hollstein M,Hergenhahn M,Yang Q,et al.New approaches to understanding p53 gene tumor mutation spectra[J].Mutat Res,1999,431(2):199-209.
  • 9[9]Chappuis P O,Estreicher A,Dieterich B,et al.Prognostic significance of p53 mutation in breast cancer:frequent detection of non-missense mutations by yeast functional assay[J].Int J Cancer,1999,84(6):587-593.
  • 10[10]Watanabe J,Nishiyama H,Okubo K,et al.Clinical evaluation of p53 mutations in urothelial carcinoma by IHC and FASAY[J].Urology,2004,63(5):989-993.

共引文献10

同被引文献33

引证文献3

二级引证文献7

临床检验杂志
2008年 第3期

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