肿瘤抑制基因p53的研究进展

Research Advance in Tumor Suppressor Gene p53

肿瘤抑制基因p53是目前研究最为广泛和系统的抑癌基因之一。野生型p53参与了DNA损伤修复、细胞周期调控、细胞凋亡及抑制血管生成等过程。p53基因的突变使上述功能丧失,从而导致肿瘤的形成。约50%的人类肿瘤中可发现p53基因的突变,且几乎可见于各种类型的肿瘤细胞中。现综述目前p53研究及相关基因治疗的进展。

p53 is one of the most extensive and systematic cancer supppressor genes that have been studied.Wild type p53 gene plays an important role in the repair of DNA damage,the control of cell cycle apoptosis and the inhibition of angiopoiesis.Mutation of p53 gene causes the lost of above functions.In about 50% human tumor cells,the mutation of p53 gene can be found,which induces the development of almost all human cancers.The advance in research of p53 gene and related gene therapy is reviewed.