摘要
目的分析HBsAg阳性少见血清学模式HBV感染者基因型。方法采用型特异性引物PCR法对深圳地区304例常见血清学模式与136例少见血清学模式HBV感染者基因型进行检测。结果常见与少见血清学模式HBV感染者基因型为B型、C型和混合型B+C,以B型和C型为主。常见血清学模式之间和少见血清学模式之间基因型构成比无显著差异(P>0.05)。结论深圳地区少见血清学模式HBV感染者基因型以B型和C型为主,其次为混合型B+C。
Objective To investigate the distribution of HBV genotypes in hepatitis B virus （HBV） carriers with infrequent serological pattern. Methods HBV genotypes were determined by nested - PCR using type - specific primers in 136 HBV carriers with infrequent serological pattern, control samples were done in 304 HBV carriers with common serological pattern. These HBV carriers lived in Shenzhen. Results Genotypes B, C and mixed B ＋ C were detected in HBV carriers with infrequent and common serological patterns. Genotypes B and C were the major genotypes. There was no statistically significant difference in the distribution of HBV genotypes（P〉0.05）. Conclusions HBV genotypes B, C, and mixed B ＋ C exist in HBV carriers with infrequent serological pattern, and genotypes B and C are the major genotypes.
出处
《实用预防医学》
CAS
2008年第2期320-322,共3页
Practical Preventive Medicine
基金
深圳市盐田区科技计划项目(NO.200406)
关键词
HBV
血清学模式
基因型
Hepatitis B virus
Serological pattern
Genotype
