脑脊液置换联合鞘内注药对结核性脑膜炎患者疗效的观察

Efficacy of CSF Exchange with Intrathecal Administration of Drugs in Treatment of Tuberculosis Meningitis

目的观察脑脊液置换联合鞘内注药对结核性脑膜炎患者脑脊液生化及腺苷脱氨酶(adenosine deainase,ADA)的影响,并探讨其疗效。方法55例结脑患者随机分为治疗组和对照组,对照组常规治疗,治疗组在常规治疗的基础上采用脑脊液置换联合鞘内注药,两个月后对两组疗效进行比较分析。结果治疗组在改善脑脊液生化指标方面均优于对照组(P<0.05)。治疗组总有效率为96.67%,治愈率为56.67%;对照组总有效率为64%,治愈率为32%,差异有统计学意义(P<0.01)。结论脑脊液置换联合鞘内注药治疗结核性脑膜炎疗效显著。

Objective To observe the effectiveness of cerebrospinal fluid replacement combining intrathecal pouring leechdom on CNS biochemistry and ADA in patients with cerebral tuberculosis. Methods Fifty - five patients were randomly assigned into treatment and control groups. On the basis of conventional intrathecal drug therapy, the treatment group received additional CSF exchange. The effective and cure rates of both groups were compared at the end of the 2nd month. Results The treatment group outstripped the control group in improvement of CSF biochemical indicator ADA （P 〈 0.05）, the total effective rate was 96.67% and cure rate was 56.67%, versus only 64% and 32% in the control group （P〈0.01） . Conclusions Oerebrospinal fluid exchange combined intrathecal drug therapy has marked curative effect in curing cerebral tuberculosis.